Heterochromatin links to centromeric protection by recruiting shugoshin

Nature
Yuya YamagishiYoshinori Watanabe

Abstract

The centromere of a chromosome is composed mainly of two domains, a kinetochore assembling core centromere and peri-centromeric heterochromatin regions. The crucial role of centromeric heterochromatin is still unknown, because even in simpler unicellular organisms such as the fission yeast Schizosaccharomyces pombe, the heterochromatin protein Swi6 (HP1 homologue) has several functions at centromeres, including silencing gene expression and recombination, enriching cohesin, promoting kinetochore assembly, and, ultimately, preventing erroneous microtubule attachment to the kinetochores. Here we show that the requirement of heterochromatin for mitotic chromosome segregation is largely replaced by forcibly enriching cohesin at centromeres in fission yeast. However, this enrichment of cohesin is not sufficient to replace the meiotic requirement for heterochromatin. We find that the heterochromatin protein Swi6 associates directly with meiosis-specific shugoshin Sgo1, a protector of cohesin at centromeres. A point mutation of Sgo1 (V242E), which abolishes the interaction with Swi6, impairs the centromeric localization and function of Sgo1. The forced centromeric localization of Sgo1 restores proper meiotic chromosome segregation in ...Continue Reading

References

Feb 5, 2000·Current Biology : CB·J F Smothers, S Henikoff
Oct 13, 2001·Science·P BernardR C Allshire
Jan 10, 2002·Nature Cell Biology·Nobuhiro NonakaYoshinori Watanabe
May 17, 2003·Science·Tomoya S KitajimaYoshinori Watanabe
Jul 13, 2004·Trends in Cell Biology·David J AmorK H Andy Choo
Jul 13, 2004·Nature Cell Biology·Tatsuo FukagawaMitsuo Oshimura
Aug 11, 2004·The Journal of Cell Biology·Mounia GuenatriGeneviève Almouzni
May 21, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alison L Pidoux, Robin C Allshire
Mar 17, 2006·Nature·Tomoya S KitajimaYoshinori Watanabe
Dec 19, 2006·Nature Reviews. Genetics·Shiv I S Grewal, Songtao Jia
Feb 27, 2007·Genes & Development·Shigehiro A KawashimaYoshinori Watanabe
Dec 18, 2007·Nature Cell Biology·Jibak LeeYoshinori Watanabe
Dec 28, 2007·Cell·Teruaki OkadaHiroshi Masumoto
Jan 5, 2008·Science·Hernan Diego FolcoRobin C Allshire

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Citations

Jan 6, 2010·EMBO Molecular Medicine·Leanne De KoningGeneviève Almouzni
Mar 25, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Marc Gartenberg
Mar 25, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Takeshi Sakuno, Yoshinori Watanabe
Jun 27, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Benjamin J AlperJanet F Partridge
Mar 13, 2014·Trends in Cell Biology·Daniele CanzioGeeta J Narlikar
Mar 30, 2013·Trends in Genetics : TIG·Kiran Mahajan, Nupam P Mahajan
Sep 29, 2009·Nature·Mark A DawsonTony Kouzarides
Apr 13, 2010·Nature Cell Biology·Tadashi IshiguroYoshinori Watanabe
May 17, 2012·Nature Reviews. Molecular Cell Biology·Yoshinori Watanabe
Jul 17, 2009·Molecular Biology of the Cell·Tessie M NgSue Biggins
Jul 29, 2009·The Journal of Heredity·Danielle VermaakHarmit S Malik
Oct 5, 2010·Genes & Development·Yuji TannoYoshinori Watanabe
Jan 9, 2010·Science·Jean-Paul Javerzat
Oct 12, 2010·Science·Yuya YamagishiYoshinori Watanabe
Nov 19, 2009·Annual Review of Genetics·Danielle Vermaak, Harmit S Malik
Jan 29, 2011·Cytogenetic and Genome Research·D Clift, A L Marston
Feb 15, 2011·BMC Cell Biology·Mai KankeHisao Masukata
Mar 10, 2010·Epigenetics & Chromatin·Alicia AlonsoPeter E Warburton
Nov 23, 2012·Epigenetics & Chromatin·Michael ThorsenGenevieve Thon
Jul 24, 2012·Genes & Genetic Systems·Yuki Ogiyama, Kojiro Ishii
Feb 10, 2011·PLoS Genetics·Ching-Shyi WuMarc R Gartenberg
Jan 1, 2014·PloS One·Adam T WatsonAntony M Carr
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Yixin Yao, Wei Dai
Aug 6, 2013·Cellular and Molecular Life Sciences : CMLS·Andreas HoubenJeremy N Timmis
Mar 13, 2014·Nature Communications·Arindam ChakrabortySupriya G Prasanth
May 9, 2012·Genetics Research International·Patrick M Ferree, Satyaki Prasad
Oct 6, 2014·Nature Genetics·Philippe ChetailleGregor Andelfinger
Nov 5, 2014·The Journal of Cell Biology·Silvana RošićSylvia Erhardt
Dec 10, 2009·The Journal of Cell Biology·Yoko Hayashi-TakanakaHiroshi Kimura
Sep 12, 2015·Science·Yuji TannoYoshinori Watanabe

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