Heterochromatin protein 1 (HP1): interactions with itself and chromatin components

Biophysics Reviews
Amarjeet Kumar, Hidetoshi Kono

Abstract

Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual structural elements of HP1 and thereby different behavior and interaction patterns. Hence, an understanding of various interactions of the structural elements of HP1 will be of utmost importance to better elucidate chromatin dynamics in its presence. In this review, we have gathered available information about interactions of HP1 both within and with itself as well as with chromatin elements. Also, the possible implications of these interactions are discussed.

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Citations

Feb 16, 2020·Biophysics Reviews·Tsuyoshi Shirai, Tohru Terada
Jan 19, 2021·Journal of Molecular Biology·Vincenzo R LobbiaHugo van Ingen
Dec 9, 2020·Biophysics Reviews·Damien Hall
Feb 3, 2021·Journal of Cell Science·Didier FesquetVéronique Baldin
Nov 10, 2020·Current Opinion in Cell Biology·Audrey Yi Tyan PengBrian C Freeman
Feb 19, 2021·Frontiers in Cellular and Infection Microbiology·Mila Collados Rodríguez

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Methods Mentioned

BETA
nuclear magnetic resonance
x-ray crystallography
NMR
electron microscopy
x-ray scattering
co-immunoprecipitation
acetylation

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