A very important open question in stem cells regulation is how the fine balance between GSCs self-renewal and differentiation is orchestrated at the molecular level. In the past several years much progress has been made in understanding the molecular mechanisms underlying intrinsic and extrinsic controls of GSC regulation but the complex gene regulatory networks that regulate stem cell behavior are only partially understood. HP1 is a dynamic epigenetic determinant mainly involved in heterochromatin formation, epigenetic gene silencing and telomere maintenance. Furthermore, recent studies have revealed the importance of HP1 in DNA repair, sister chromatid cohesion and, surprisingly, in positive regulation of gene expression. Here, we show that HP1 plays a crucial role in the control of GSC homeostasis in Drosophila. Our findings demonstrate that HP1 is required intrinsically to promote GSC self-renewal and progeny differentiation by directly stabilizing the transcripts of key genes involved in GSCs maintenance.
Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster
Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene.
Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos
A unique ribonucleoprotein complex assembles preferentially on ecdysone-responsive sites in Drosophila melanogaster.
Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila
A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line
decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
DDP1, a single-stranded nucleic acid-binding protein of Drosophila, associates with pericentric heterochromatin and is functionally homologous to the yeast Scp160p, which is involved in the control of cell ploidy
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell
Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin
Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila
Drosophila DDP1, a multi-KH-domain protein, contributes to centromeric silencing and chromosome segregation
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin
The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis
Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila
Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II
Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary
Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice
The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster
Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells
Control of germline stem cell self-renewal and differentiation in the Drosophila ovary: concerted actions of niche signals and intrinsic factors
Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary
Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms
Telomerase reverse transcriptase downregulation by RNA interference modulates endoplasmic reticulum stress and mitochondrial energy production.
Various modes of HP1a interactions with the euchromatic chromosome arms in Drosophila ovarian somatic cells
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.
An RNA-interference screen in Drosophila to identify ZAD-containing C2H2 zinc finger genes that function in female germ cells.
Adult Stem Cells
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.