PMID: 9634484Jun 20, 1998Paper

Heterochronic differences of Hoxa-11 expression in Xenopus fore- and hind limb development: evidence for lower limb identity of the anuran ankle bones

Development Genes and Evolution
M J BlancoG P Wagner

Abstract

The wrist (carpus) and ankle (tarsus) of most tetrapods, as well as the wrist of anurans, contains relatively small nodular skeletal elements. The anuran tarsus, however, comprises a pair of long bones, the proximal tarsals tibiale and fibulare, which resemble the lower leg bones, tibia and fibula (zeugopodium). In this paper we investigate whether the proximal tarsals of Xenopus are of zeugopodial character identity, i.e. whether they develop under the influence of the same genes that pattern the lower limb. We compare Hoxa-11 expression in the forelimb bud with that in the hind limb bud by whole-mount in situ hybridization. Hoxa-11 has been implicated in the development of the lower limb. In Xenopus we note three differences between Hoxa-11 expression in fore- and hind limb buds: (1) Hoxa-11 expression is maintained until the hind limb bud reaches a larger size (2 mm) than that of the forelimb bud (1.5 mm); (2) Hoxa-11 expression is maintained over larger spatial domains than in the forelimb; and (3) Hoxa-11 expression has a pronounced posterior polarity in the hind limb, but not in the forelimb. Hind limb expression of Hoxa-11 can be understood as a heterochronic prolonging of the expression dynamic in the forelimb. Finally ...Continue Reading

Citations

Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B K Hall, T Miyake
Feb 26, 2013·Trends in Genetics : TIG·Igor Schneider, Neil H Shubin
Feb 23, 2007·Biological Reviews of the Cambridge Philosophical Society·Gregory R Handrigan, Richard J Wassersug
Aug 10, 2012·EvoDevo·Constanze BickelmannMarcelo R Sánchez-Villagra
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C O LovejoyT D White
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KimG S Min
Aug 10, 2002·Evolution & Development·Jonathan E JefferyMichael K Richardson
Jan 12, 2005·Evolution & Development·Monique C M WeltenMichael K Richardson
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·F Canillas del ReyE Delgado-Baeza
Jan 9, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Michael K RichardsonMarcelo R Sánchez-Villagra
Dec 15, 2007·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Philip L RenoC Owen Lovejoy
Nov 21, 2013·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Rui Diogo, Janine M Ziermann
Nov 21, 2000·Molecular Phylogenetics and Evolution·C H ChiuG P Wagner
Jul 27, 2001·Mechanisms of Development·A Lombardo, J M Slack
Jun 1, 2016·ACS Synthetic Biology·Jonathan PascalieRené Doursat
Aug 11, 2016·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Philip L RenoJasmine E Hines
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hitoshi YokoyamaHiroyuki Ide
Dec 26, 2001·The Journal of Experimental Zoology·J HankenM W Klymkowsky
Jun 10, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Marissa FabreziMariana Chuliver Pereyra
Oct 13, 2001·The Journal of Experimental Zoology·G P Wagner, C H Chiu
Mar 31, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Constanze BickelmannNadia Belinda Fröbisch
Oct 11, 2017·Integrative and Comparative Biology·Alexander O VargasVicente Muñoz-Walther
Nov 27, 2018·PLoS Biology·Nayuta Yakushiji-KaminatsuiDenis Duboule
May 10, 2005·Journal of Morphology·R Adam FranssenNeil Shubin
Nov 22, 2020·Zoology : Analysis of Complex Systems, ZACS·Tamara G PetrovićNataša Tomašević Kolarov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.