Abstract
The association between heterocyclic aromatic amine (HCA) intake and prostate cancer (PCa) risk may be modified by genetic variation in enzymes involved in HCA metabolism. We examined this question in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition Heidelberg cohort. The study included 204 PCa cases and 360 matched controls. At baseline, participants provided dietary and lifestyle data and blood samples that were used for genotyping. Dietary HCA intake-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP), 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-dimethylimidazo [4,5-f]quinoxaline (DiMeIQx-was estimated using information on meat consumption, cooking methods, and browning degree. Risk estimates for gene × HCA interactions were calculated by unconditional logistic regression. We found inverse associations between PhIP, MeIQx, or DiMeIQx intake and PCa risk when having <2 deletions of the GSTT1 and GSTM1 genes (P(interaction): 0.03, 0.01, and 0.03, respectively), which is supported by analysis of darkly browned meat consumption data. Statistically significant effect modification of both HCA (DiMeIQx) and darkly browned meat intake and PCa risk w...Continue Reading
References
Jul 30, 1999·Carcinogenesis·C Y WangG P Haas
Dec 2, 1999·Journal of the National Cancer Institute·A E NorrishR T Jackson
Dec 11, 1999·Annals of Nutrition & Metabolism·H BoeingM M Bergmann
Dec 11, 1999·Annals of Nutrition & Metabolism·M M BergmannH Boeing
Aug 30, 2000·Carcinogenesis·J A WilliamsD H Phillips
Feb 24, 2001·The Journal of Nutrition·E Riboli
Oct 10, 2002·Public Health Nutrition·Sabine Rohrmann, Nikolaus Becker
Feb 3, 2005·Prostate Cancer and Prostatic Diseases·P M RovitoG P Haas
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Oscar A Di PaoloFred F Kadlubar
Dec 17, 2005·Cancer Research·Amanda J CrossRashmi Sinha
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Deliang TangBenjamin A Rybicki
Oct 24, 2007·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M S AlaejosA M Afonso
Dec 7, 2007·Cancer Research·Stuart K CretonNigel J Gooderham
Jan 18, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stella KoutrosRashmi Sinha
Mar 1, 2008·The British Journal of Nutrition·Sabine RohrmannJakob Linseisen
Feb 19, 2009·Cancer Research·Stella KoutrosAmanda J Cross
Mar 6, 2009·The American Journal of Clinical Nutrition·Sabine RohrmannJakob Linseisen
Mar 25, 2009·Carcinogenesis·Antonio AgudoCarlos A González
Oct 8, 2009·American Journal of Epidemiology·Rashmi SinhaAmanda J Cross
Oct 20, 2009·Nutrition and Cancer·Wei Zheng, Sang-Ah Lee
Dec 17, 2009·Journal of Cancer Research and Clinical Oncology·Chen MaoQing Chen
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Astrid SteinbrecherJakob Linseisen
Jun 24, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sangita SharmaLoïc Le Marchand
Jul 28, 2010·Nutrition and Cancer·Guillermo GervasiniAgustin Cabanillas
Sep 21, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Astrid SteinbrecherJakob Linseisen
Nov 26, 2010·Cancer Causes & Control : CCC·Anja SanderSabine Rohrmann
Citations
Nov 29, 2012·PloS One·Mancheng GongRuihua An
Feb 1, 2013·PloS One·Qing YangXin Yao
Jun 8, 2014·American Journal of Epidemiology·Tian-Biao ZhouYuan-Han Qin
Jan 13, 2015·Nutrients·Karen S BishopLynnette R Ferguson
Feb 20, 2016·Journal of Clinical Medicine·Georgia Lenihan-GeelsLynnette R Ferguson
Feb 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying Jin, Zengping Hao
Nov 29, 2015·Technology in Cancer Research & Treatment·Zhong-Yang WangGregor P C Drummen
Nov 9, 2016·Asian Journal of Sports Medicine·Ahmad AzadAghaali Ghasemnian
Jan 14, 2020·Aging·Li-Feng ZhangLi-Jie Zhu
Nov 1, 2017·Journal of the American College of Nutrition·Barbara KlánováJulie Bienertová-Vašků
Sep 25, 2018·Disease Markers·Ping WangYanle Zhang
Oct 30, 2016·The International Journal of Biological Markers·Xiao LiJie Li
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·Xiaoqian ChenYu Zhang
Apr 2, 2019·Journal of Agricultural and Food Chemistry·Dan SongRong Liu
Jul 1, 2014·Nutrition & Metabolism·Dalvinder MandairMartyn Evan Caplin