Heterocyclic aromatic amine [HCA] intake and prostate cancer risk: effect modification by genetic variants

Nutrition and Cancer
Mieke Van HemelrijckJakob Linseisen

Abstract

The association between heterocyclic aromatic amine (HCA) intake and prostate cancer (PCa) risk may be modified by genetic variation in enzymes involved in HCA metabolism. We examined this question in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition Heidelberg cohort. The study included 204 PCa cases and 360 matched controls. At baseline, participants provided dietary and lifestyle data and blood samples that were used for genotyping. Dietary HCA intake-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP), 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-dimethylimidazo [4,5-f]quinoxaline (DiMeIQx-was estimated using information on meat consumption, cooking methods, and browning degree. Risk estimates for gene × HCA interactions were calculated by unconditional logistic regression. We found inverse associations between PhIP, MeIQx, or DiMeIQx intake and PCa risk when having <2 deletions of the GSTT1 and GSTM1 genes (P(interaction): 0.03, 0.01, and 0.03, respectively), which is supported by analysis of darkly browned meat consumption data. Statistically significant effect modification of both HCA (DiMeIQx) and darkly browned meat intake and PCa risk w...Continue Reading

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Citations

Jun 8, 2014·American Journal of Epidemiology·Tian-Biao ZhouYuan-Han Qin
Feb 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying Jin, Zengping Hao
Nov 29, 2015·Technology in Cancer Research & Treatment·Zhong-Yang WangGregor P C Drummen
Nov 9, 2016·Asian Journal of Sports Medicine·Ahmad AzadAghaali Ghasemnian
Jan 14, 2020·Aging·Li-Feng ZhangLi-Jie Zhu
Nov 1, 2017·Journal of the American College of Nutrition·Barbara KlánováJulie Bienertová-Vašků
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·Xiaoqian ChenYu Zhang
Jul 1, 2014·Nutrition & Metabolism·Dalvinder MandairMartyn Evan Caplin

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Methods Mentioned

BETA
PhIP
genotyping
acetylator
sulfotransferase

Software Mentioned

BioGlobe
Statistical Analysis Systems ( SAS )

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