PMID: 25751009Mar 10, 2015Paper

Heterocyclic Scaffolds: Centrality in Anticancer Drug Development

Current Drug Targets
Imran AliMohd Marsin Sanagi

Abstract

Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer. Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides, some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds have also been discussed. Finally, the suggestions for syntheses of...Continue Reading

Citations

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Jul 1, 2020·Combinatorial Chemistry & High Throughput Screening·Yaojian JinMingxing Ding
Jul 18, 2020·Combinatorial Chemistry & High Throughput Screening·Mohammad FazilImran Ali

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