PMID: 2109937Apr 1, 1990Paper

Heterogeneities in regional volumes of distribution and flows in rabbit heart

The American Journal of Physiology
F Gonzalez, J B Bassingthwaighte

Abstract

The heterogeneity of volumes of distribution in the heart influences the rates of uptake and washout of substrates and metabolites; thus it is important to evaluate their variability in the normal heart. Several tracers were injected intravenously into anesthetized adult closed-chest rabbits, and time was allowed for equilibration in the heart. Tracer microspheres were injected into the left ventricular cavity at the apex for the measurement of regional flows, the chest was opened, another set of microspheres was injected, and the heart was frozen rapidly in situ with liquid nitrogen-cooled Freon-22. Each heart was divided into 72 pieces of less than 0.1 g weight, and the tracer content of each was determined by multichannel gamma-counting and the water content by desiccation. The regional myocardial flows were (closed chest) 0.62 +/- 0.16 ml.g-1.min-1 and (open chest) 0.63 +/- 0.37 ml.g-1.min-1. The volumes of distribution (ml/g) for the 432 pieces for six rabbits, given as mean +/- SD (% coefficient of variation), were as follows: for plasma, VP = 0.11 +/- 0.03 (26%); erythrocytes, VRBC = 0.041 +/- 0.015 (37%); vascular space, VV = 0.15 +/- 0.04 (26%); extracellular space, VECF = 0.33 +/- 0.05 (15%); interstitial space, VISF ...Continue Reading

Citations

Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·U SchwankeJ D Schipke
Aug 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Renee J Filion, Aleksander S Popel
May 7, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bartholomew Jardine, James B Bassingthwaighte
Mar 13, 2014·Physics in Medicine and Biology·Michael BindschadlerAdam M Alessio
Mar 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·N WilkeA E Stillman
Dec 1, 1995·Circulation Research·J B Bassingthwaighte, D A Beard
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L M SchwartzJ B Bassingthwaighte
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michael R Kellen, James B Bassingthwaighte
Jun 16, 2006·Annals of Biomedical Engineering·Ranjan K Dash, James B Bassingthwaighte
Jun 13, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·James B BassingthwaighteThomas R Bukowski
Jul 19, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Daniel A BeardEric O Feigl
May 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Michael R Kellen, James B Bassingthwaighte

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