PMID: 6166708Apr 1, 1981Paper

Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes

The Journal of Experimental Medicine
T J BracialeV L Braciale

Abstract

Continuous lines of murine cytotoxic T lymphocytes (CTL) directed to type A influenza viruses have been generated in vitro by stimulation of individual CTL precursors in the presence of T cell-growth factor TCGF and syngeneic virus-infected stimulator cells. The cloned CTL lines are H-2 restricted in their target cell recognition and exhibit distinct patterns of influenza virus recognition. All CTL lines appear to be restricted in target cell recognition to either the H-2K or the H-2D end of the appropriate H-2 haplotype. Likewise, CTL lines of F1 origin are restricted in recognition exclusively to one of the parental haplotypes. All CTL lines examined express the Thy-1.2 and the Lyt-2-surface antigen markers. 4 of 11 cytotoxic lines examined also expressed detectable levels of the Lyt-1- surface antigen. These findings confirm at the clonal level previous observations on the H-2K/D restriction of virus-specific CTL and also demonstrate heterogeneity among H-2 restricted CTL both from the standpoint of viral antigen recognition and cell surface phenotype.

References

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Citations

Sep 1, 1990·Journal of Cellular Physiology·O M Pereira-SmithF M Orson
Jan 1, 1983·Immunogenetics·A R TownsendB A Askonas
Jan 1, 1989·Immunogenetics·G MorahanL Malcolm
Jan 1, 1987·Immunologic Research·A R Townsend
Sep 1, 1985·Cellular Immunology·G SterkersJ P Lévy
Jul 30, 1982·Journal of Immunological Methods·W Haas, H Von Boehmer
Sep 1, 1984·Veterinary Immunology and Immunopathology·M Miller-Edge, G A Splitter
Jun 1, 1987·Human Immunology·J R LambJ B Rothbard
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T J BracialeV L Braciale
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HahnC M Rice
Aug 1, 1982·The Journal of Experimental Medicine·V L BracialeT J Braciale
Mar 1, 1983·The Journal of Experimental Medicine·D W LanckiF W Fitch
Feb 1, 1984·The Journal of Experimental Medicine·L AndrusE Reich
Sep 1, 1984·The Journal of Experimental Medicine·A E LukacherT J Braciale
Nov 1, 1993·The Journal of Experimental Medicine·M B GrahamT J Braciale
Apr 1, 1996·The Journal of Experimental Medicine·M T EsserV L Braciale
May 16, 1998·The Journal of Experimental Medicine·M T EsserV L Braciale
Aug 1, 1987·Immunological Reviews·T J BracialeV L Braciale

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