Heterogeneity between hippocampal and septal astroglia as a contributing factor to differential in vivo AMPA excitotoxicity

Journal of Neuroscience Research
M J RodríguezN Mahy

Abstract

Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected in the hippocampus and the medial septum and a time-course study was carried out between 2 hr and 3 days. When compared to controls, microinjection of alpha-AA in the hippocampus induced within 3 days a reversible loss of glial fibrillary acidic protein (GFAP) immunostaining and a microglial reaction without any neuronal loss, whereas in the medial septum it caused no effects on astroglial, microglial, or neuronal populations. Differences in hippocampus and medial septum vulnerability were also evidenced when alpha-AA was co-injected with AMPA and neurodegeneration was assessed in terms of neuronal loss, glial reactions, calcification, and atrophy of the area. In the hippocampus, alpha-AA increased AMPA excitotoxicity with marked disorganization of all hippocampal subfields, increased neuronal loss, a more important astroglial reaction, a larger area of microgliosis, and a greater abundance of calcium deposits. By c...Continue Reading

References

Sep 1, 1992·Neurochemical Research·W T NortonC F Brosnan
Sep 1, 1992·Neuropharmacology·R J BridgesC W Cotman
Feb 1, 1990·Trends in Neurosciences·G P WilkinA J Cholewinski
Mar 1, 1989·Neurology·E EllieX Ferrer
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 1, 1994·Current Opinion in Neurology·R S Rust
Feb 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E Hösli, L Hösli
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
Mar 24, 1998·Brain Research Bulletin·G Gegelashvili, A Schousboe
Jun 3, 1998·Journal of Neurocytology·D R Brown, H A Kretzschmar
Apr 24, 1999·The European Journal of Neuroscience·Z Q Xiong, J L Stringer
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M J RodríguezN Mahy
Apr 14, 2000·Brain Research. Molecular Brain Research·F López-RedondoS Kohsaka
Feb 13, 2001·Neurobiology of Disease·M J RodríguezN Mahy
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi NishiyamaShigeyoshi Itohara
Mar 23, 2002·Science·Eric C BeattieRobert C Malenka
May 3, 2002·Nature·Clive N Svendsen
May 3, 2002·Nature·Hongjun SongFred H Gage
Jan 28, 2003·Neurochemistry International·Lorraine BrennanGethin J McBean
Apr 22, 2003·Journal of Neuroscience Research·Noemí AndrésNicole Mahy

❮ Previous
Next ❯

Citations

Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yong-Jing Gao, Ru-Rong Ji
Apr 13, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jang-Mi ParkMun-Yong Lee
Sep 10, 2005·Journal of Neurochemistry·Romain Daniel GosselinStéphane Melik-Parsadaniantz
Nov 14, 2008·Journal of Neuroscience Research·Fabián BernalNicole Mahy
Jul 12, 2013·Oxidative Medicine and Cellular Longevity·Manuel J RodríguezNicole Mahy
May 16, 2015·BioMed Research International·Montserrat BatlleManuel J Rodríguez
Dec 3, 2005·Journal of Neuroscience Research·David RamonetNicole Mahy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.