PMID: 7545265Sep 1, 1995Paper

Heterogeneity in chemical mutagen-induced chromosome damage after G2 phase exposure to bleomycin, ara-C and gentian violet in cultured lymphocytes of beta-thalassaemia traits

Mutation Research
A P Krishnaja, N K Sharma

Abstract

Chemical mutagen-induced chromosome damage was analysed in cultured peripheral blood lymphocytes from beta-thalassaemia traits and healthy individuals. This was promoted by the fact that beta-thalassaemia trait is present in 1-17% of different population groups in India. To study mutagen-induced chromosome instability, G2 lymphocytes were exposed to bleomycin, ara-C or gentian violet in 48-h cultures. Spontaneous chromosome aberration frequencies in lymphocytes from beta-thalassaemia traits were found to be in the normal range. In all three clastogen-treated lymphocytes from beta-thalassaemia traits, there is a degree of hypersensitivity, when the results are averaged over a number of individuals, but some individuals overlap within the normal range. The heterogeneity in chemical mutagen sensitivity observed in beta-thalassaemia traits is discussed in terms of the oxidative damage consequent on the genetic and biochemical features peculiar to the beta-thalassaemia trait cell.

References

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TakeshitaH Ohtsubo
Mar 1, 1991·Mutation Research·L F Povirk, M J Austin
Jun 1, 1991·British Journal of Haematology·N Y VarawallaD J Weatherall
Jul 16, 1981·Biochemical and Biophysical Research Communications·S AkiyamaM Kuwano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.