Heterogeneity in Malignant Pleural Mesothelioma

International Journal of Molecular Sciences
Kathrin OehlMayura Meerang

Abstract

Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.

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Methods Mentioned

BETA
exome-sequencing
chromosomal aberrations
methylation profiling
xenograft
biopsy

Clinical Trials Mentioned

NCT01592383
NCT00137826
NCT00039182
NCT00787410
NCT00025207
NCT00597116
NCT00996567

Software Mentioned

COSMIC

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