Heterogeneity in subcellular muscle glycogen utilisation during exercise impacts endurance capacity in men.

The Journal of Physiology
Rasmus JensenJoachim Nielsen

Abstract

When muscle biopsies first began to be used routinely in research on exercise physiology five decades ago, it soon become clear that the muscle content of glycogen is an important determinant of exercise performance. Glycogen particles are stored in distinct pools within the muscles, but the role of each pool during exercise and how this is affected by diet is unknown. Here, the effects of diet and exercise on these pools, as well as their relation to endurance during prolonged cycling were examined. We demonstrate here that an improved endurance capacity with high carbohydrate loading is associated with a temporal shift in the utilisation of the distinct stores of glycogen pools and is closely linked to the content of the glycogen pool closest to actin and myosin (intramyofibrillar glycogen). These findings highlight the functional importance of distinguishing between different subcellular microcompartments of glycogen in individual muscle fibres. In muscle cells, glycogen is stored in three distinct subcellular pools: between or within myofibrils (inter- and intramyofibrillar glycogen, respectively) or beneath the sarcolemma (subsarcolemmal glycogen) and these pools may well have different functions. Here, we investigated the...Continue Reading

References

Sep 1, 1979·Acta Physiologica Scandinavica·H GalboN J Christensen
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·K MadsenE A Richter
Jul 31, 1986·Biochemical and Biophysical Research Communications·D Danieli BettoR Betto
Nov 1, 1985·Acta Physiologica Scandinavica·N K Vøllestad, P C Blom
Nov 15, 1973·Pflügers Archiv : European journal of physiology·P D GollnickB Saltin
Aug 1, 1974·Acta Physiologica Scandinavica·D L CostillB Saltin
Nov 1, 1973·Acta Physiologica Scandinavica·D L CostillE M Stein
Sep 1, 1971·Journal of Applied Physiology·B Pernow, B Saltin
Oct 1, 1967·Acta Physiologica Scandinavica·J BergströmB Saltin
Sep 1, 1982·Muscle & Nerve·M SjöströmT Scherstén
Jan 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M SjöströmK A Angquist
Oct 15, 1993·The Biochemical Journal·E Meléndez-HeviaE D Shelton
Jul 1, 1996·The American Journal of Clinical Nutrition·L M BurkeM Hargreaves
Jul 1, 1996·Metabolism: Clinical and Experimental·A E JeukendrupJ M Wagenmakers
Apr 1, 1996·The Journal of Physiology·J W HelgeB Kiens
Feb 1, 1996·Medicine and Science in Sports and Exercise·A JeukendrupA D Kester
Aug 1, 1996·Journal of Applied Physiology·O K TsintzasP Greenhaff
Apr 4, 1998·Medicine and Science in Sports and Exercise·J W HelgeB Kiens
Dec 22, 1999·Journal of Applied Physiology·M A Febbraio, J Dancey
Jun 14, 2000·Journal of Applied Physiology·J L WalkerL L Spriet
Jun 16, 2001·Journal of Applied Physiology·M A TarnopolskyS M Phillips
May 1, 1965·Journal of Neurophysiology·E HENNEMAN, C B OLSON
Nov 15, 2003·Journal of Neurophysiology·Alexander Adam, Carlo J De Luca
Mar 20, 2004·BMJ : British Medical Journal·Marion K CampbellUNKNOWN CONSORT group
Aug 11, 2005·Canadian Journal of Physiology and Pharmacology·T A DuhamelJ Ouyang
Mar 3, 2007·Pflügers Archiv : European journal of physiology·Trent StellingwerffLuc J C van Loon
Jan 16, 2008·Physiological Reviews·D G AllenH Westerblad
Sep 19, 2008·Medicine and Science in Sports and Exercise·Gareth A WallisAsker E Jeukendrup
Jan 15, 2009·The Biochemical Journal·Hilal ZaidAmira Klip
Feb 27, 2009·Upsala Journal of Medical Sciences·Stefan BranthGunnar Ronquist
Apr 3, 2009·The Journal of Biological Chemistry·Clara PratsJørgen F P Wojtaszewski
Sep 23, 2010·American Journal of Physiology. Endocrinology and Metabolism·Joachim NielsenNiels Ortenblad
Dec 24, 2010·The Journal of Experimental Biology·Stephen T KinseyRichard M Dillaman
Jan 18, 2011·Experimental Physiology·Clara PratsAndreas V Hansen
Aug 1, 2013·Physiological Reviews·Erik A Richter, Mark Hargreaves

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Citations

Aug 10, 2020·The Journal of Physiology·Jonathan S Fisher
Oct 1, 2020·The Journal of Physiology·Bryan Saunders, Nathan Gobbi
Feb 17, 2021·Nature Communications·Anders B KleinChristoffer Clemmensen
Apr 27, 2021·Sports Medicine·Jeppe F Vigh-LarsenMagni Mohr
Mar 26, 2021·Journal of Applied Physiology·Yoanna M Ivanova, Denis P Blondin

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