Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma.

Journal for Immunotherapy of Cancer
Kevin T LynchIleana S Mauldin

Abstract

Tertiary lymphoid structures (TLSs) are immune aggregates in peripheral tissues that may support adaptive immune responses. Their presence has been associated with clinical response to checkpoint blockade therapy (CBT), but it is unknown whether TLS have prognostic significance independent of CBT in melanoma. We hypothesized that TLS in melanoma metastases would be associated with increased intratumoral lymphocyte infiltration, but that the intra-TLS immunological milieu would be distinct from the intratumoral immunological milieu. We also hypothesized that the presence of TLS would be associated with improved survival, and that TLS maturation or intra-TLS lymphocyte activity would also correlate with survival. Cutaneous melanoma metastases (CMM) from 64 patients were evaluated by multiplex immunofluorescence for the presence and maturation status of TLS. Intra-TLS lymphocyte density, proliferation and B-cell Ig somatic hypermutation (AID+) were analyzed, as were markers of T-cell exhaustion and Th1/Tc1 differentiation. Associations between TLS maturation and intra-TLS immunologic activity were assessed, as well as associations with intratumoral immune cell infiltration. Independent associations with overall survival (OS) were ...Continue Reading

References

Oct 11, 2002·Annals of Surgical Oncology·Peter J Allen, Daniel G Coit
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claudia WehrKlaus Warnatz
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Jan 10, 2012·The Lancet Oncology·Joannes F M JacobsGosse J Adema
Jul 14, 2012·Journal of Translational Medicine·Wenshi WangJeffrey S Weber
Aug 2, 2012·Cancer Research·Arcadi CipponiNicolas van Baren
Apr 13, 2013·Current Opinion in Immunology·Helen Angell, Jérôme Galon
Jul 23, 2013·The Journal of Clinical Investigation·Beatriz M CarrenoGerald P Linette
May 2, 2014·Pathology Oncology Research : POR·Andrea LadányiJózsef Tímár
Apr 29, 2015·Current Opinion in Virology·Nicole A Doria-Rose, M Gordon Joyce
Nov 29, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H-M HsiaoD Kreisel
Apr 29, 2016·Oncotarget·Thomas V GuyBarbara Fazekas de St. Groth
Jul 15, 2016·Scientific Reports·Louise SaulSophia N Karagiannis
Jan 9, 2018·The Journal of Clinical Investigation·Rituparna DasKavita M Dhodapkar
Jan 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor H EngelhardCraig L Slingluff
Mar 15, 2018·Melanoma Research·Anne M StowmanCraig L Slingluff
Sep 5, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jessica Da Gama DuarteJonathan M Blackburn
Jan 9, 2019·Frontiers in Immunology·Jing LiChen Dong
May 17, 2019·Nature Reviews. Cancer·Catherine Sautès-FridmanWolf Herman Fridman
Nov 17, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin DizierFernando Ulloa-Montoya
Jan 11, 2020·Frontiers in Immunology·Jessica D Gereige, Paul J Maglione
Jan 17, 2020·Nature·Beth A HelminkJennifer A Wargo

❮ Previous
Next ❯

Software Mentioned

Vectra
InForm
Phenochart

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Cancer Immunotherapy

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.