Heterogeneity in the presence of CD4-like molecules on human spermatozoa

Andrologia
D K Dimitrova-DikanarovaR N Fichorova

Abstract

The object of the present study was to study if there are differences in the presence of CD4-like molecules on human ejaculated spermatozoa in fertile donors and infertile patients (with globozoospermia). Indirect and absorption enzyme-linked immunosorbent assay and indirect immunofluorescence were applied. The enzyme-linked immunosorbent assay data showed that monoclonal anti-human CD4-antibody recognizes an epitope common to the human spermatozoa with normal morphology and round-headed spermatozoa. Localization of the antigenic determinants, identified by anti-human CD4-monoclonal antibody, in the acrosomal region, including equatorial segment, postnuclear cap and tail was determined in normozoospermic samples. A positive reaction was found on the sperm head both in the acrosomal and postacrosomal region of some round-headed spermatozoa in the samples with globozoospermia. The tails of the normozoospermic spermatozoa and of some round-headed spermatozoa were weakly immunopositive. The results of the experiments carried out are evidence of heterogeneity in the presence of CD4-like antigen determinants on human spermatozoa. These data increased the information about the CD4-antigen characteristic of the spermatozoa from fertile...Continue Reading

References

Jul 1, 1975·Fertility and Sterility·W L Johnson, A C Menge
Feb 26, 1990·FEBS Letters·B GobertG Faure
Nov 1, 1985·The Tohoku Journal of Experimental Medicine·K Takeda, K Hiraiwa
Jan 1, 1981·American Journal of Reproductive Immunology : AJRI·S MathurH H Fudenberg
Nov 1, 1994·The Journal of Cell Biology·B BaccettiA Massacesi
Mar 1, 1993·Journal of Reproductive Immunology·A JassimY al-Zuhdi
Nov 1, 1995·Human Reproduction·T GilA Herruzo
Dec 1, 1984·Immunology Today·K James, T B Hargreave

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Citations

Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S ChenJ M White
May 9, 2019·American Journal of Reproductive Immunology : AJRI·Charlene D YoungNongnuj Tanphaichitr
Jul 14, 2017·Zygote : the Biology of Gametes and Early Embryos·William Borges DominguesVinicius Farias Campos
Sep 30, 2006·Human Reproduction Update·A H D M DamJ A M Kremer
Jul 28, 2020·Virus Research·Antoinette Cornelia van der Kuyl, Ben Berkhout

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