Heterogeneity in the Segmental Development of the Aortic Tree: Impact on Management of Genetically Triggered Aortic Aneurysms

Aorta : Official Journal of the Aortic Institute at Yale-New Haven Hospital
Hisham M F Sherif

Abstract

An extensive search of the medical literature examining the development of the thoracic aortic tree reveals that the thoracic aorta does not develop as one unit or in one stage: the oldest part of the thoracic aorta is the descending aorta with the aortic arch being the second oldest, developing under influence from the neural crest cell. Following in chronological order are the proximal ascending aorta and aortic root, which develop from a conotruncal origin. Different areas of the thoracic aorta develop under the influence of different gene sets. These parts develop from different cell lineages: the aortic root (the conotruncus), developing from the mesoderm; the ascending aorta and aortic arch, developing from the neural crest cells; and the descending aorta from the mesoderm. Findings illustrate that the thoracic aorta is not a single entity, in developmental terms. It develops from three or four distinct areas, at different stages of embryonic life, and under different sets of genes and signaling pathways. Genetically triggered thoracic aortic aneurysms are not a monolithic group but rather share a multi-genetic origin. Identification of therapeutic targets should be based on the predilection of certain genes to cause aneu...Continue Reading

Citations

Jan 16, 2018·American Journal of Medical Genetics. Part a·Ming Hui ChenChristopher A Walsh
May 23, 2015·Expert Review of Cardiovascular Therapy·Laura Muiño Mosquera, Julie De Backer
Sep 4, 2021·Nitric Oxide : Biology and Chemistry·Arash Y TehraniPascal Bernatchez

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