PMID: 9186751May 30, 1997Paper

Heterogeneity of 5-HT receptors mediating secretion in the human intestine

Annals of the New York Academy of Sciences
R A Borman, D E Burleigh

Abstract

In conclusion, application of 5-HT has been shown to induce fluid secretion in both the small and large intestine of man. By the use of selective antagonists, the receptors mediating these effects have been identified and characterized. 5-HT induces secretion across human ileal mucosa via a receptor of the 5-HT4 sub-type, whereas a receptor of the 5-HT2A sub-type appears to mediate the effect in human sigmoid colon. The response in human ascending colonic mucosa cannot be definitively classified at this time, but may reflect the presence of a heterogenous receptor population.

Citations

Apr 10, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·D T Beattie, J A M Smith
Sep 2, 2000·European Journal of Pharmacology·A I AlcaldeA Lahuerta
Jan 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael Camilleri
Mar 12, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Viktória DénesRobert Gábriel
Aug 9, 2008·Neuropharmacology·Robin Spiller
Apr 27, 2011·International Journal of Experimental Pathology·Ashok R GunawardeneCarolyn A Staton
Aug 28, 2007·Experimental Biology and Medicine·Sharon DemorrowGianfranco Alpini
Mar 2, 1999·British Journal of Pharmacology·M HemedahF J Mitchelson

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