Heterogeneity of amygdala response in major depressive disorder: the impact of lifetime subthreshold mania.

Psychological Medicine
J C FournierMary L Phillips

Abstract

Patients with major depressive disorder (MDD) present with highly heterogeneous symptom profiles. We aimed to examine whether individual differences in amygdala activity to emotionally salient stimuli were related to heterogeneity in lifetime levels of depressive and subthreshold manic symptoms among adults with MDD. We compared age- and gender-matched adults with MDD (n = 26) with healthy controls (HC, n = 28). While undergoing functional magnetic resonance imaging, participants performed an implicit emotional faces task: they labeled a color flash superimposed upon initially neutral faces that dynamically morphed into one of four emotions (angry, fearful, sad, happy). Region of interest analyses examined group differences in amygdala activity. For conditions in which adults with MDD displayed abnormal amygdala activity versus HC, within-group analyses examined amygdala activity as a function of scores on a continuous measure of lifetime depression-related and mania-related pathology. Adults with MDD showed significantly greater right-sided amygdala activity to angry and happy conditions than HC (p < 0.05, corrected). Multiple regression analyses revealed that greater right-amygdala activity to the happy condition in adults wi...Continue Reading

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Citations

May 15, 2013·Lancet·Mary L Phillips, David J Kupfer
Oct 25, 2017·Cognitive, Affective & Behavioral Neuroscience·Jamie FerriDaniel H Mathalon
Oct 22, 2015·Brain Imaging and Behavior·Bei ZhangXiang Wang
Feb 15, 2019·Expert Review of Neurotherapeutics·Trisha Chakrabarty, Lakshmi N Yatham

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