Heterogeneity of antigen expression and lectin labeling on microglial cells in the olfactory bulb of adult rats

Neuroscience Research
C H WuE A Ling

Abstract

Microglia in different layers of the rat olfactory bulb expressed a variety of membrane antigens except for CD4 (OX-35). Bulb microglial cells bearing complement receptor type 3 (OX-42) were ubiquitous and their immunoreactivity varied considerably in different bulb layers. Although very few in number, labeled microglia in all layers also expressed major histocompatibility complex class I antigen (OX-18), leukocyte common antigen (OX-1) and unknown macrophage antigen (ED-2). The latter was localized in cells distributed almost exclusively in the perivascular spaces. The immunoreactivity of ED-1, an unknown cytoplasmic or lysosomal membrane antigen in macrophages, was localized in labeled microglia which were concentrated mainly in the granule cell layer and periglomerular zone of the bulb. A variable number of microglial cells were stained with OX-6 (major histocompatibility complex class II antigen) and they were located predominantly in the periglomerular zone and at the junction between the granule cell layer and the subependymal layer. Ultrastructural study using GSA I-B4 lectin labeling showed that microglia in different layers of the bulb exhibited similar labeling patterns in their subcellular structures. A remarkable fe...Continue Reading

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Citations

Mar 23, 2000·Neuroscience·B K Fiske, P C Brunjes
Jun 26, 2003·Journal of Pineal Research·Ya Fen Jiang-ShiehChen Yuan Wen
Oct 4, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lindsay M De Biase, Antonello Bonci
May 31, 2007·Toxicology and Industrial Health·Nickolette RoneyChristopher T De Rosa
Jan 9, 2019·Frontiers in Cellular Neuroscience·Sara BachillerAntonio Boza-Serrano
Jun 11, 2021·The European Journal of Neuroscience·Tomohiro OhgomoriShozo Jinno
Jul 6, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Delphine Boche, Marcia N Gordon

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