Heterogeneity of capillary density of skin over the dorsum of the foot and toes of healthy subjects

International Journal of Microcirculation, Clinical and Experimental
M LamahJ A Dormandy

Abstract

The spatial pattern of capillaries is one of many factors important for the optimisation of oxygen and nutrient delivery in a specified region of tissue. One area of particular interest to the vascular specialist is the skin of the dorsum of the foot and toes, as these are especially prone to ulceration in patients with arterial disease. The aim of this study was therefore to establish the extent of capillary density (CD) heterogeneity in the normal skin of the dorsum of the foot and toes, since any great non-uniformity might produce regions of low perfusion, which may become vulnerable to ulceration. Using white-light (native) videomicroscopy at a magnification of x 40 in 15 healthy subjects (mean age 72 years), the dorsum of the foot and toes was systematically mapped by determining the CD at each of 25 sites on the dorsum of the foot, and at 2 sites on the distal phalanx of each toe. Off-line analysis of videoprints was then undertaken to determine CD at each site, according to a fixed protocol of measurement and data analysis. The mean value and spatial coefficient of variation of CD was then calculated for each foot. There was striking spatial heterogeneity of CD in the dorsum of the foot, some areas having low numbers of ...Continue Reading

Citations

Mar 24, 2004·Micron : the International Research and Review Journal for Microscopy·Terence Ryan
Jan 3, 2001·British Journal of Clinical Pharmacology·A C Shore
Jul 2, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M LamahJ A Dormandy
Apr 14, 1999·The British Journal of Surgery·M LamahJ A Dormandy
Oct 6, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Jeff S IsenbergDavid D Roberts

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