PMID: 20126864Feb 4, 2010Paper

Heterogeneity of carboxyl-terminal parathyroid hormone circulating forms in patients with hyperparathyroidism due to end stage renal disease

Arquivos brasileiros de endocrinologia e metabologia
José Gilberto H VieiraAluizio B Carvalho

Abstract

To study carboxyl-terminal (COOH) parathyroid hormone (PTH) circulating forms in patients with hyperparathyroidism due to end stage renal disease (ESRD). An immunometric assay that recognizes both intact and COOH PTH forms was developed. The assay, in conjunction with an intact assay, was used to measure PTH in serum samples obtained from 25 patients with hyperparathyroidism due to ESRD. Samples were also submitted to gel filtration chromatography in a Superdex((R)) 30 1.6 x 60 cm column, and the PTH content in the elution tubes, measured using both assays. Values from 39.000 to 232.300 ng/mL (mean +/- sd = 101.680 +/- 45.330 ng/mL) were found using the COOH assay (PTH 39-84 was used as standard). Values obtained by the intact PTH assay ranged from 318 to 3.307 ng/mL (1.769 +/- 693 ng/mL) with a correlation between assays of 0.462 (p = 0.02). The elution profile obtained using the COOH assay showed a preponderance of forms with MW ranging from 8.500 to 4.500 daltons. The profiles obtained from the 25 patients were very similar. In patients with hyperparathyroidism due to ESRD circulating PTH levels contain a broad range of molecular forms including COOH with MW ranging from 8.500 to 4.500 daltons. These forms are not recognized...Continue Reading

References

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Nov 22, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I S Kunii, J G Vieira
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Nov 23, 2006·Arquivos brasileiros de endocrinologia e metabologia·José Gilberto H VieiraSônia Nishida

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Citations

Feb 3, 2016·Biotechnology Advances·Brian M CumminsGlenn M Walker
Nov 5, 2016·Archives of Endocrinology and Metabolism·Teresa Cristina P BonanséaJosé Gilberto Henriques Vieira
May 2, 2012·Journal of Osteoporosis·Jose Gilberto H Vieira
Jan 22, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Andre Albuquerque SilveiraFabio Luiz de Menezes Montenegro

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