PMID: 6539237Jan 1, 1984Paper

Heterogeneity of cell response to early anoxia and reoxygenation in rat heart

Experimental Pathology
P M Rahamathulla, M Ashraf

Abstract

Heterogeneous cell injury and increased tissue calcium levels were observed in the isolated rat hearts perfused with anoxic medium for 5, 10, 15, 20, 25 and 30 min. These changes were intensified after reoxygenation of the anoxic hearts. The cell injury was quantitated using a score of 0, 1, 2 or 3 (0 being normal and 3 being severe injury). All four classes of cells were present even after 5 min of anoxia. The injury and calcium content increased with increase in duration of anoxia. Reduction in the percentage of injured cells was observed on reoxygenation of hearts perfused with anoxic medium for 5 to 20 min. However, reoxygenation of hearts initially perfused with anoxic medium for 25 to 30 min resulted in a higher percentage of injured myocytes. Beneficial effects of reoxygenation were observed in the anoxic hearts when the percentage of cells with an injury score of 1 and glycogen deposit were high, coupled with low calcium levels.

References

Apr 1, 1979·Journal of Molecular and Cellular Cardiology·C E Ganote, J P Kaltenbach
Jul 1, 1978·Journal of Molecular and Cellular Cardiology·D J HearseG R Bullock
Oct 1, 1976·Journal of Molecular and Cellular Cardiology·D J HearseJ De Leiris
Aug 1, 1973·Journal of Molecular and Cellular Cardiology·D J HearseE B Chain
Apr 1, 1983·Journal of the American College of Cardiology·P M RahamathullaJ Benedict
Jan 1, 1981·Journal of Molecular and Cellular Cardiology·C E GanoteJ P Kaltenbach

❮ Previous
Next ❯

Citations

Jul 1, 1989·Basic Research in Cardiology·M Ashraf, P M Rahamathulla
Dec 1, 1987·Pathology, Research and Practice·H KobayashiM Minami

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.