Heterogeneity of cerebral capillary flow in man and its consequences for estimation of blood-brain barrier permeability

The Journal of Clinical Investigation
M M Hertz, O B Paulson

Abstract

Blood-brain barrier permeability studies made in man using the indicator dilution method revealed that the extraction of the test substance increases during the upslope of the venous (outflow) dilution curve. The present study aimed to obviate the possibility that this could result from intravascular phenomena, such as interlaminar diffusion (the result of differences in molecular size) and erythrocyte carriage. Several reference substances were employed for the determination of the extraction in order that careful correction could be made for differences in intravascular behavior of the test and reference substance. The test substances studied were D-glucose, L-phenylalanine, water, propranolol, and benzodiazepines, representing both carrier-transported and lipophilic substances. In-diethylenetriamine pentaacetic acid, Na+, Cl-, L-glucose, and L-lysine were employed as reference substances. For all the substances tested, and after correction for intravascular phenomena, the extractions were found to increase during the initial part of the dilution curve. This increasing extraction can be ascribed to heterogeneity of the cerebral circulation; the higher extraction corresponds to longer contact with the blood-brain barrier and i...Continue Reading

References

Dec 1, 1978·European Journal of Clinical Investigation·O B Paulson, M M Hertz
Apr 1, 1977·European Journal of Clinical Investigation·T G BolwigO J Rafaelsen
Jan 1, 1977·Microvascular Research·O B PaulsonN A Lassen
Mar 1, 1973·Circulation Research·P BrodersenN A Lassen

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Citations

Oct 10, 2001·Journal of Neuroscience Research·L LibrizziM de Curtis
Jan 1, 1981·Pharmacology & Therapeutics·J D FenstermacherC S Patlak
Dec 1, 1990·Clinical and Experimental Pharmacology & Physiology·P J Robinson
Mar 1, 1981·The Journal of Clinical Investigation·M M HertzP A Svendsen
May 1, 1992·Journal of Neurochemistry·M P DehouckJ P Tillement
May 16, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew J P Barrett, Vinod Suresh
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Erik F HauckOliver Kempski
Sep 10, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Olaf B PaulsonDale Pelligrino
Jul 23, 2013·Clinical Physiology and Functional Imaging·Jens H HenriksenHenrik B W Larsson
Jul 1, 1982·Clinical and Experimental Pharmacology & Physiology·L Bass, P J Robinson
Sep 11, 2012·Experimental Parasitology·James Edwards-SmallboneRobin J Flynn
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Vogel, W Kuschinsky
Feb 2, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshiaki Itoh, Norihiro Suzuki
Dec 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R J HargreavesV J Cunningham
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G M KnudsenO B Paulson
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G M KnudsenM M Hertz
Aug 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y SawadaM Hanano
Aug 24, 1999·European Journal of Clinical Investigation·G M KnudsenO B Paulson
Aug 1, 1985·Circulation Research·M W Bradbury
Dec 1, 1995·Circulation Research·I G KassissiaG G Bach
Jun 1, 1981·European Journal of Clinical Investigation·M L FriisT G Bolwig
Dec 11, 1992·Pharmaceutisch Weekblad. Scientific Edition·J B Van BreeD D Breimer
May 1, 1981·Acta Neurologica Scandinavica·M M HertzE Westergaard

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