PMID: 2507767Oct 1, 1989Paper

Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilation

The Journal of Pediatrics
O PrydsB Friis-Hansen

Abstract

The reaction of cerebral blood flow to acute changes in arterial carbon dioxide pressure (PaCO2) and mean arterial blood pressure was determined in 57 preterm infants supported by mechanical ventilation (mean gestational age 30.1 weeks) during the first 48 hours of life. All infants had normal brain sonograms at the time of the investigation. In each infant, global cerebral blood flow was determined by xenon-133 clearance two to five times within a few hours at different levels of PaCO2. Changes in PaCO2 followed adjustments of the ventilator settings. Arterial oxygen pressure was intended to be kept constant, and mean arterial blood pressure fluctuated spontaneously between measurements. The data were analyzed by stepwise multiple regression, with changes in global cerebral blood flow, PaCO2, mean arterial blood pressure, and postnatal age or intracranial hemorrhage used as variables. In infants with persistently normal brain sonograms, the global cerebral blood flow-carbon dioxide reactivity was markedly lower during the first day of life (mean 11.2% to 11.8%/kPa PaCO2) compared with the second day of life (mean 32.6/kPa PaCO2), and pressure-flow autoregulation was preserved. Similarly, global cerebral blood flow-carbon dioxi...Continue Reading

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Citations

Jun 14, 2006·Pediatric Radiology·Corinne VeyracCatherine Baud
May 1, 1994·Electroencephalography and Clinical Neurophysiology·H E FrissM R Wolfson
Aug 27, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elise A VerhagenElisabeth M W Kooi
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Jul 10, 2010·Journal of Biomedical Optics·Turgut DurduranDaniel J Licht

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