PMID: 6162860Mar 1, 1981Paper

Heterogeneity of DNA deletion in gamma delta beta-thalassemia

The Journal of Clinical Investigation
S H OrkinD G Nathan

Abstract

By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N J Proudfoot, F E Baralle
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J G MearsA Bank
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S H OrkinD G Nathan
Mar 1, 1979·Cell·D J Weatherall, J B Clegg
Sep 1, 1979·The Journal of Clinical Investigation·S H OrkinC Altay
Jan 20, 1972·The New England Journal of Medicine·Y W KanD G Nathan
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W R JelinekC W Schmid
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R E KaufmanA W Nienhuis
Sep 19, 1980·Science·C P LiuF R Blattner
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J F GusellaD Housman

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Citations

Jan 1, 1985·Human Genetics·S E AntonarakisS H Orkin
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M C DriscollB P Alter
Apr 25, 1985·Nucleic Acids Research·M W JenningsD J Weatherall
Oct 1, 1981·The Journal of Clinical Investigation·R F TrecartinA Cao
Aug 1, 1983·The Journal of Clinical Investigation·M PirastuC T Holbrook
Oct 1, 1985·The Journal of Clinical Investigation·P CurtinH Lehmann
Sep 11, 2007·Seminars in Perinatology·Laurie A Steiner, Patrick G Gallagher
Sep 27, 2003·British Journal of Haematology·Laurence GameSwee Lay Thein
May 1, 1982·British Journal of Haematology·E KanavakisW G Wood
Jan 1, 1982·Journal of Cellular Physiology. Supplement·O Smithies
Aug 4, 2009·American Journal of Hematology·Sara C KoenigDavid H K Chui
Feb 1, 1982·American Journal of Hematology·M H Steinberg, J G Adams
Feb 2, 2010·Hemoglobin·Amel Haj KhelilPascale Perrin
Jun 29, 2000·Baillière's Clinical Haematology·S L Thein
Mar 1, 1993·Baillière's Clinical Haematology·S L Thein

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