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Heterogeneity of dN/dS ratios at the classical HLA class I genes over divergence time and across the allelic phylogeny

bioRxiv

Aug 22, 2014

Bárbara Domingues BitarelloDiogo Meyer

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Abstract

The classical class I HLA loci of humans show an excess of nonsynonymous with respect to synonymous substitutions at codons of the antigen recognition site (ARS), a hallmark of adaptive evolution. Additionally, high polymporphism, linkage disequilibrium and disease associations suggest ...read more

Mentioned in this Paper

Silent Mutation
Dysequilibrium Syndrome
Genetic Linkage
Supernumerary Maxillary Right Lateral Primary Incisor
Codon (Nucleotide Sequence)
Phenotype Determination
Equilibrium
Genes
Placement Action
Depth
8
5
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  • Heterogeneity of dN/dS ratios at the classical HLA class I genes over divergence time and across the allelic phylogeny

    bioRxiv

    Aug 22, 2014

    Bárbara Domingues BitarelloDiogo Meyer

    PMID: 990008342

    DOI: 10.1101/008342

    Abstract

    The classical class I HLA loci of humans show an excess of nonsynonymous with respect to synonymous substitutions at codons of the antigen recognition site (ARS), a hallmark of adaptive evolution. Additionally, high polymporphism, linkage disequilibrium and disease associations suggest ...read more

    Mentioned in this Paper

    Silent Mutation
    Dysequilibrium Syndrome
    Genetic Linkage
    Supernumerary Maxillary Right Lateral Primary Incisor
    Codon (Nucleotide Sequence)
    8
    5

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