Heterogeneity of genetic architecture of body size traits in a free-living population.

Molecular Ecology
Camillo BerenosJosephine M Pemberton

Abstract

Knowledge of the underlying genetic architecture of quantitative traits could aid in understanding how they evolve. In wild populations, it is still largely unknown whether complex traits are polygenic or influenced by few loci with major effect, due to often small sample sizes and low resolution of marker panels. Here, we examine the genetic architecture of five adult body size traits in a free-living population of Soay sheep on St Kilda using 37 037 polymorphic SNPs. Two traits (jaw and weight) show classical signs of a polygenic trait: the proportion of variance explained by a chromosome was proportional to its length, multiple chromosomes and genomic regions explained significant amounts of phenotypic variance, but no SNPs were associated with trait variance when using GWAS. In comparison, genetic variance for leg length traits (foreleg, hindleg and metacarpal) was disproportionately explained by two SNPs on chromosomes 16 (s23172.1) and 19 (s74894.1), which each explained >10% of the additive genetic variance. After controlling for environmental differences, females heterozygous for s74894.1 produced more lambs and recruits during their lifetime than females homozygous for the common allele conferring long legs. We also de...Continue Reading

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Aug 19, 2015·Experimental Gerontology·Adam D HaywardDaniel H Nussey
Oct 17, 2015·Scientific Reports·Jiaxue CaoLixin Du
Feb 3, 2016·Molecular Ecology·Timothy J Thurman, Rowan D H Barrett
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Feb 28, 2021·Molecular Ecology·S Eryn McFarlaneJosephine M Pemberton
Apr 6, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Otto SeppäläCoen M Adema
Nov 1, 2021·Molecular Ecology·Bilal AshrafJon Slate

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Methods Mentioned

BETA
genotyping
chip

Software Mentioned

asreml
custom
GRAMMAR
gcta
R package LDheatmap
beagle
R scripts
MCMCglmm
plink
r package

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