PMID: 11916167Mar 28, 2002Paper

Heterogeneity of HLA-DRB1*04 and its associated haplotypes in the North Indian population

Human Immunology
R JainiN K Mehra

Abstract

HLA-DR4 has been implicated in several diseases including rheumatoid arthritis (RA) and type I diabetes, the strength of associations being ethnically variable. Unusually high level of heterogeneity in DR4-DQB1 haplotypes has been reported in the Indian population. The present study is an attempt to determine the genetic diversity of the HLA-DR4 allelic family and its associated DQA1-DQBI haplotypic combinations in the healthy North Indian population. Using PCR-SSP and PCR-SSOP techniques, nine subtypes of DR4 were encountered of which DRB1*0403 was the most predominant allele (34.8%) followed by *0404 (27%), *0401 (14.6%), and *0405 (11%). No examples of *0402, *0409, *0411, *0413-*0417, and *0419-23 were encountered, although a few other subtypes, *0410 (three examples), *0406 and *0418 (two examples each), and *0407, *0408, and *0412 (single example each) occurred infrequently in a cohort of 85 HLA-DR4 positive samples studied. Most of these subtypes occurred in combination with DQA1*03-DQB1*0302 (69.5%). DRB1*0403 and *0404 exhibited maximum heterogeneity of DQB1 combinations. Haplotype data revealed the presence of 15 different DR4-DQ haplotypes, four of which were found to be "unique" to Asian Indians, not reported in any...Continue Reading

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Citations

May 25, 2012·Rheumatology International·Devaraj Jatteppa ParasannanavarKanjaksha Ghosh
Jan 1, 2004·Human Immunology·Uma KangaNarinder K Mehra
Jul 18, 2002·Human Immunology·Gurvinder KaurN K Mehra
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Surendra K SharmaNarinder K Mehra
Feb 8, 2013·Annals of the New York Academy of Sciences·Neeraj KumarNarinder K Mehra
Feb 7, 2013·Annals of the New York Academy of Sciences·Narinder K MehraGurvinder Kaur
Aug 7, 2014·Journal of Ophthalmic Inflammation and Infection·Joanne Yw NgChi-Pui Pang
Mar 24, 2015·Molecular and Clinical Oncology·Mervat M El AnsaryAlshymaa A Ahmed
Sep 1, 2004·Human Immunology·Umapathy Shankarkumar, Balakrisnan Sridharan
Nov 1, 2006·Expert Review of Clinical Immunology·Narinder Mehra, Gurvinder Kaur
Aug 27, 2005·European Journal of Epidemiology·Yogita GhodkeBhushan Patwardhan

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