Heterogeneity of Human Pancreatic Islet Isolation Around Europe: Results of a Survey Study.

Transplantation
Rita NanoLorenzo Piemonti

Abstract

Europe is currently the most active region in the field of pancreatic islet transplantation, and many of the leading groups are actually achieving similar good outcomes. Further collaborative advances in the field require the standardization of islet cell product isolation processes, and this work aimed to identify differences in the human pancreatic islet isolation processes within European countries. A web-based questionnaire about critical steps, including donor selection, pancreas processing, pancreas perfusion and digestion, islet counting and culture, islet quality evaluation, microbiological evaluation, and release criteria of the product, was completed by isolation facilities participating at the Ninth International European Pancreas and Islet Transplant Association (EPITA) Workshop on Islet-Beta Cell Replacement in Milan. Eleven islet isolation facilities completed the questionnaire. The facilities reported 445 and 53 islet isolations per year over the last 3 years from deceased organ donors and pancreatectomized patients, respectively. This activity resulted in 120 and 40 infusions per year in allograft and autograft recipients, respectively. Differences among facilities emerged in donor selection (age, cold ischemia ...Continue Reading

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Citations

Jul 25, 2019·Diabetes·Rita NanoLorenzo Piemonti
Nov 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Freya Van HulleDaniel Pipeleers
Dec 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Piotr WitkowskiUNKNOWN “Islets for US” Collaborative
Mar 3, 2021·Current Opinion in Organ Transplantation·Riccardo Tamburrini, Jon S Odorico
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers

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