Nov 8, 2018

Heterogeneity of Incipient Atrophy Patterns in Parkinson’s Disease

BioRxiv : the Preprint Server for Biology
Pedro Doria MaiaAshish Raj

Abstract

Parkinson's Disease (PD) is a the second most common neurodegenerative disorder after Alzheimer's disease and is characterized by cell death in the amygdala and in substructures of the basal ganglia such as the substantia nigra. Since neuronal loss in PD leads to measurable atrophy patterns in the brain, there is clinical value in understanding where exactly the pathology emerges in each patient and how incipient atrophy relates to the future spread of disease. A recent seed-inference algorithm combining an established network-diffusion model with an L1-penalized optimization routine led to new insights regarding the non-stereotypical origins of Alzheimer's pathologies across individual subjects. Here, we leverage the same technique to PD patients, demonstrating that the high variability in their atrophy patterns also translates into heterogeneous seed locations. Our individualized seeds are significantly more predictive of future atrophy than a single seed placed at the substantia nigra or the amygdala. We also found a clear distinction in seeding patterns between two PD subgroups – one characterized by predominant involvement of brainstem and ventral nuclei, and the other by more widespread frontal and striatal cortices. This...Continue Reading

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Mentioned in this Paper

Patterns
Entire Brainstem
Neurons
Brain
Alzheimer's Disease
Entire Basal Nuclei
Substantia Nigra Structure
Ventral Posterior Nucleus
Parkinson's Disease and Parkinsonism
Neuronal

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