Heterogeneity of intrahepatic fat distribution determined by (18)F-FDG PET and CT

Annals of Nuclear Medicine
G KeramidaAdrien M Peters

Abstract

Hepatic steatosis is common but less is known of the heterogeneity of hepatic fat distribution and its clinical significance. Our objective was to measure the regional variabilities within the liver of standardised uptake values (SUV) as potential markers of hepatic fat distribution heterogeneity. Twenty-four patients having routine, clinically indicated PET/CT with (18)F-FDG and a wide range of fatty liver severity were selected. Maximum SUV (SUVmax), average SUV (SUVave), both calculated using lean body mass, and CT density were measured in 12 × 2-cm diameter ROIs in each patient. SUVave was also measured over the left ventricular cavity (SUVLV). Mean values of SUV indices, their ratios with SUVLV, and CT density in the 12 ROIs were calculated. Regional variabilities of SUV indices were expressed as coefficients of variation (CV; standard deviation/mean). Body mass index (BMI) was estimated from height and body weight, and %body fat and lean body mass from height, weight and gender. Mean SUVmax/SUVave correlated significantly with mean CT density (r = -0.51; p < 0.02). In contrast, mean SUVmax, mean SUVave and their ratios with SUVLV showed no correlation with CT density. Mean CT density correlated with weight (r = -0.59; p <...Continue Reading

References

Jul 1, 1997·Journal of Hepatology·C RicciL Dalla Palma
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Taner ErselcanSemra Ozdemir
Oct 7, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gonca G BuralAbass Alavi
Feb 23, 2010·AJR. American Journal of Roentgenology·Cody J BoyceJ Louis Hinshaw
Feb 24, 2010·Radiology·Jonathan T Abele, Christopher I Fung
Dec 24, 2010·AJR. American Journal of Roentgenology·Gad AbikhzerChris Rush
Jul 20, 2011·BMJ : British Medical Journal·Quentin M AnsteeChristopher P Day
Feb 22, 2012·Insights Into Imaging·Patrick-Olivier DécarieAn Tang
Sep 12, 2012·Annals of Surgery·Vatche G AgopianRonald W Busuttil
Oct 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Sugama ChickloreGary J R Cook
Dec 19, 2013·Journal of Magnetic Resonance Imaging : JMRI·Michael J HouseTim G St Pierre
Mar 4, 2014·European Journal of Radiology·Georgia KeramidaA Michael Peters
Aug 26, 2014·AJR. American Journal of Roentgenology·Georgia KeramidaAdrien M Peters
Apr 23, 2015·European Radiology·Georgia KeramidaA Michael Peters

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Citations

Jun 13, 2020·Clinical Physiology and Functional Imaging·Georgia Keramida, A Michael Peters

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