Heterogeneity of low density lipoprotein responses to fish-oil supplementation in hypertriglyceridemic subjects

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
G SchectmanA H Kissebah

Abstract

Previous studies have demonstrated a variable effect of fish oil on low density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B levels, particularly in hypertriglyceridemic subjects. Since heterogeneity of LDL composition and metabolism in hypertriglyceridemic subjects is well described, the present study was undertaken to determine if the response of LDL to dietary fish-oil supplementation is dependent upon pretreatment differences in LDL composition. A single-blind, cross-over design was used with 18 hypertriglyceridemic subjects, who were given supplements of a safflower-oil placebo or a fish-oil concentrate (4.0 g omega-3 fatty acids; [F4 dose]) for 1 month. Sixteen subjects then received an additional month of fish-oil supplementation at a higher dose (7.5 g omega-3 fatty acids [F7.5 dose]). The initial LDL cholesterol/apo B ratio, an index of LDL composition, was correlated positively with changes in LDL apo B levels (F4.0 dose: r = 0.41, p = 0.06; F7.5 dose: r = 0.51, p = 0.03) and negatively with changes in LDL cholesterol concentrations (F4.0 dose: r = -0.51, p = 0.01; F7.5 dose: r = -0.50, p = 0.02). Twelve subjects with LDL cholesterol/apo B ratios above 1.4 had large increases in LDL apo B (51% at both dose...Continue Reading

References

Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Jul 1, 1987·Diabetes/metabolism Reviews·A H Kissebah
May 1, 1986·The American Journal of Clinical Nutrition·P J Nestel
Jul 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G L Vega, S M Grundy
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S G YoungS Bernstein
May 9, 1985·The New England Journal of Medicine·B E PhillipsonD R Illingworth
Sep 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T A SandersG R Thompson
Dec 18, 1972·Annals of the New York Academy of Sciences·J G Bieri
Mar 1, 1983·The Journal of Clinical Investigation·A H KissebahP W Adams
Nov 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A H KissebahD J Evans
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B TengP O Kwiterovich
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D R IllingworthW E Connor
Jul 1, 1984·The Journal of Clinical Investigation·P J NestelR Boston
Feb 1, 1980·European Journal of Clinical Investigation·A ChaitJ D Brunzell
Dec 1, 1982·Annals of Internal Medicine·A D SnidermanP O Kwiterovich

❮ Previous
Next ❯

Citations

Apr 1, 1996·Diabetologia·J D BagdadeP V Subbaiah
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H J Bilo, R O Gans
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·T A Sanders
Jun 30, 1998·Current Opinion in Lipidology·B A Griffin
Jun 1, 2000·Australian and New Zealand Journal of Medicine·C B SingletonT J Campbell
Apr 1, 1995·BMJ : British Medical Journal·B N PrichardD J Betteridge
Jun 11, 2004·Annual Review of Nutrition·Vasuki Wijendran, K C Hayes
Jun 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Samman
Jun 11, 2008·The American Journal of Clinical Nutrition·Un Ju JungRichard J Deckelbaum
Jan 3, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·U N Das
Sep 1, 1995·Metabolism: Clinical and Experimental·S E Kasim-KarakasR Almario
Oct 1, 1990·Atherosclerosis·J S Parks, L L Rudel

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.