Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease.

Journal of Innate Immunity
Janet S Lee

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease defined by an aberrant inflammatory response to inhaled cigarette smoke and other noxious particles. The factors triggered in the lungs that drive inflammation and lung tissue destruction are not fully understood, but mononuclear phagocytes play a central role by releasing mediators that promote both inflammation and tissue-destructive emphysema. Although conflicting studies on alveolar macrophages exist regarding chronic cigarette smoke exposure and its effects on macrophage polarization patterns, we have recently identified a cell type in mice defined by CX3CR1 expression. The population of this cell type expands in the lungs and elaborates M1 signature cytokines in response to cigarette smoke exposure in vivo. In addition, the absence of functional CX3CR1 provides protection from tissue-destructive emphysema in a murine model of chronic cigarette smoke exposure. The heterogeneity and plasticity of discrete macrophage subsets, in terms of immunophenotype and function, may explain the seemingly disparate findings showing a suppressed inflammatory profile on the one hand and a heightened inflammatory response on the other. This review examines the evidence that discrete ...Continue Reading

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Citations

May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Alexander V MisharinHarris Perlman
Dec 1, 2013·Annals of the American Thoracic Society·Pieter S Hiemstra
Sep 25, 2014·Immunology Letters·Phyllis-Jean Linton, Marilyn L Thoman
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May 17, 2017·Frontiers in Immunology·Faezzah BaharomAnna Smed-Sörensen
Nov 6, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mark H KuniholmAlison Morris

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