Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes.

The Journal of Allergy and Clinical Immunology. in Practice
Anne M FitzpatrickDavid T Mauger

Abstract

Compared with adults, phenotypic characterization of children with asthma is still limited and it remains difficult to predict which children with asthma are at highest risk for poor outcomes. To identify latent classes in a large population of treatment-adherent children with mild to moderate asthma enrolled in clinical trials and determine whether latent class assignment predicts future lung function abnormalities and exacerbation rate. Latent class analysis was performed on 2593 children with mild to moderate asthma aged 5 18 years, with 19 variables encompassing demographic characteristics, medical history, symptoms, lung function, allergic sensitization, and type 2 inflammation. Outcomes included lung function and the annualized exacerbation rate at 12 months of follow-up. Five latent classes were identified with differing demographic features, asthma control, sensitization, type 2 inflammatory markers, and lung function. Exacerbation rates were 1.30 ± 0.12 for class 1 (multiple sensitization with partially reversible airflow limitation), 0.90 ± 0.05 for class 2 (multiple sensitization with reversible airflow limitation), 0.87 ± 0.08 for class 3 (lesser sensitization with reversible airflow limitation), 0.87 ± 0.05 for cla...Continue Reading

Citations

Mar 3, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Michael SalvermoserBianca Schaub
Feb 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Maria ÖdlingInger Kull
Mar 31, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Sheel N ShahAnne M Fitzpatrick
Apr 10, 2021·Journal of Asthma and Allergy·Hacer Ilbilge Ertoy Karagol, Arzu Bakirtas
May 8, 2021·American Journal of Respiratory and Critical Care Medicine·Polly F M RobinsonSejal Saglani
Sep 17, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanna CilluffoStefania La Grutta

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