PMID: 8951486Nov 1, 1996Paper

Heterogeneity of mitotic activity in breast cancer

Histopathology
I JanninkJ P Baak

Abstract

The aim of this study was to investigate to what extent mitotic activity index assessments are influenced by tumour heterogeneity. Ten invasive breast carcinomas of varying size were completely embedded, yielding 2-7 paraffin blocks per tumour. From each block, three H&E stained skip sections were cut and, in all sections, the mitotic activity index (MAI) and the mitoses per volume (M/V-)index were assessed. Coefficients of variation were calculated for the three different sampling levels (tumours, blocks, sections). In addition we recorded in how many tumours threshold discrepancies (values on both sides of the prognostic thresholds) occurred. Nested analysis of variance showed that most of the total variance occurred between the tumours. Threshold discrepancies occurred in four (40%) and five tumours (50%) for mitotic activity index and the mitoses per volume index, respectively. However, when grouping all sections from the same tumour and subjectively selecting the one showing the highest proliferation, the section with the highest mitotic activity was selected in nine of the 10 cases. In the other single case a prognostically correct value was still obtained. Thus, there is a noteworthy intra-tumour heterogeneity in mitotic...Continue Reading

Citations

Mar 18, 2005·Journal of Mathematical Biology·Youshan Tao, Qian Guo
Mar 6, 1999·Breast Cancer Research and Treatment·D L PageJ F Simpson
Feb 15, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Einar GudlaugssonJan P A Baak
Oct 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ivar SkalandJan P A Baak
Oct 8, 1998·Histopathology·S S Cross
Apr 2, 1998·Histopathology·F B Thunnissen, T Ambergen
Jun 29, 2004·Journal of Clinical Pathology·P J van DiestJ P A Baak
Feb 19, 1999·Journal of Clinical Pathology·P J van DiestJ P Baak
May 31, 2002·Journal of Clinical Pathology·C F Lindboe, S H Torp
May 4, 2010·Journal of Neurosurgery. Pediatrics·Oguz CataltepeThomas W Smith
Oct 14, 2004·Virchows Archiv : an International Journal of Pathology·Victor Piana de Andrade, Helenice Gobbi
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fa-Ke LuX Sunney Xie
Dec 29, 1998·Human Pathology·P KronqvistY Collan
Nov 27, 1999·British Journal of Cancer·L P MarsonJ M Dixon
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J F SimpsonN J Robert
Sep 25, 2021·Journal of Clinical Pathology·Asmaa IbrahimEmad Rakha

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