Heterogeneity of molecular size and antigenic expression within lipooligosaccharides of individual strains of Neisseria gonorrhoeae and Neisseria meningitidis.

Infection and Immunity
H SchneiderJ M Griffiss


We determined the Mr of neisserial lipooligosaccharides (LOS) by using discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis, minimal loading concentrations, and Salmonella isogenic rough mutant LOS as Mr standards. Salmonella LOS were resolved into three components. The migration distance of each component was linearly related to its theoretical Mr (r = 0.99). Neisserial LOS also contained multiple components whose calculated Mr ranged from 3,200 to 7,100. The relative abundance of components and their MrS varied greatly among strains. Meningococcal LOS were composed almost exclusively of two closely migrating components; gonococcal LOS were more heterogeneous. LOS from a gonococcus selected for resistance to a Pseudomonas pyocin contained only a single component that was different from and of intermediate Mr among the three components of the parent strain. A monoclonal antibody directed against the meningococcal L8 LOS epitope was used to determine whether heterogeneity of antigen expression reflected Mr heterogeneity. Single components of the L8 meningococcal LOS and of the LOS of 3 of 19 gonococcal strains bound the monoclonal antibody. Gonococcal LOS components that expressed the L8 epitope were of a simi...Continue Reading


Aug 1, 1976·The Journal of Infectious Diseases·E C TramontM S Artenstein
Apr 1, 1973·The Journal of Infectious Diseases·D L KasperM S Artenstein
Jan 1, 1969·Acta Pathologica Et Microbiologica Scandinavica·J A Maeland
Jun 1, 1969·European Journal of Biochemistry·C GalanosO Westphal
Jan 1, 1982·Analytical Biochemistry·C M Tsai, C E Frasch
Oct 15, 1982·Journal of Immunological Methods·H Schneider, J M Griffiss
Sep 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·M J OSBORN

❮ Previous
Next ❯


Jan 1, 1996·Critical Reviews in Microbiology·A PrestonM A Apicella
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D H WyllieS K Dower
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunita GulatiSanjay Ram
Jun 12, 2013·Nature Reviews. Microbiology·Brittany D Needham, M Stephen Trent
Mar 1, 1986·Journal of Periodontal Research·T Hofstad, B Aadnegard
Jan 1, 1990·Scandinavian Journal of Infectious Diseases. Supplementum·M A Salih
Nov 1, 1990·Biomedical & Environmental Mass Spectrometry·N J PhillipsJ M Griffiss
Jun 1, 1995·Molecular Microbiology·J P van Putten, B D Robertson
Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M GriffissJ J Kim
Mar 29, 2000·The Journal of Biological Chemistry·J McLeod GriffissW Zollinger
Mar 7, 2002·International Reviews of Immunology·S GulatiP A Rice
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michele M EstabrookGary A Jarvis
Aug 21, 2012·The Journal of Infectious Diseases·Stephanie E McLaughlinJ McLeod Griffiss
Aug 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·J A Maeland, S Smeland
Jan 1, 1995·Molecular Microbiology·E T SchwanJ P van Putten
May 1, 1993·Molecular Microbiology·B D RobertsonJ P van Putten
Nov 2, 2001·Sexually Transmitted Diseases·K A SchmidtJ M Griffiss
Mar 20, 2003·Journal of Bacteriology·Ying Du, Cindy Grove Arvidson
Dec 1, 1986·Scandinavian Journal of Dental Research·T HofstadN Skaug
Jan 1, 1987·Antonie van Leeuwenhoek·J M GriffissM A Apicella
Mar 6, 1998·Infection and Immunity·M M EstabrookM A Apicella
Jan 1, 1996·Microbiology·J S Evans, M C J Maiden
Mar 16, 2019·Frontiers in Immunology·Sunita GulatiPeter A Rice
Feb 23, 2000·Analytical Biochemistry·K NodaR Yamasaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.