PMID: 45888Jan 1, 1975

Heterogeneity of morphological, cytochemical, and cytogenetic features in the blastic phase of chronic granulocytic leukemia

M T ShawR E Nordquist


Possible predictive criteria of the refractoriness to therapy of the blastic phase of Ph-1-positive chronic granulocytic leukemia (CGL) have been sought. Eight cases in the blastic phase were studied. The blasts were noted to be of two types: some displayed a high nuclear:cytoplasmic ratio with deep blue cytoplasm, while others had a comparatively low nuclear:cytoplasmic ratio and bluish gray cytoplasm containing a few small granules. Electron microscopic studies showed a variety of features, including defective organelles and giant mitochondria. Cytochemical staining revealed the majority of blast cells to be peroxidase- and Sudan black-negative; granular PAS positivity was the rule. Serial cytogenetic studies demonstrated increasing aneuploidy. Bone marrow biopsy showed myelofibrotic changes in two cases. Two patients entered complete remission with prednisone and vincristine and with Ara-C and thioguanine, respectively. It is concluded that the blastic phase of CGL may manifest heterogeneity.


Jan 1, 1983·Cancer Metastasis Reviews·L Olsson
Mar 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M D FoadiG D Pegrum
May 14, 1981·The New England Journal of Medicine·H P Koeffler, D W Golde
Mar 1, 1978·Archives of Disease in Childhood·I M HannD I Evans
Jan 1, 1985·Cancer Investigation·S L Allen, M Coleman
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Jan 1, 1978·American Journal of Hematology·J C Barton, M E Conrad
Dec 1, 1985·American Journal of Hematology·F M O'Malley, O M Garson
Feb 1, 1982·American Journal of Hematology·I Shah-ReddyU Khilanani
Nov 1, 1977·Scandinavian Journal of Haematology·F MandelliG Papa


Feb 1, 1974·American Journal of Clinical Pathology·M T Shaw, V A Klemp
Jan 1, 1972·Annals of Internal Medicine·A Theologides
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Sep 1, 1960·Experimental Cell Research·P S MOORHEADD A HUNGERFORD
Mar 1, 1965·Cancer·G W MORROWW A BENNETT

Related Concepts

Remission, Spontaneous
Aneuploid Cell
Alkaline Phosphatase
Acute Disease
Cell Nucleus
Tioguanina Wellcome
Leukemia, Monocytic, Chronic

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