Heterogeneity of neurogenic responses in intra- and extrameningeal arteries of dogs

British Journal of Pharmacology
Y KohnoI Muramatsu

Abstract

1. Neurogenic responses to transmural electrical stimulation were examined in endothelium-denuded extrameningeal (vertebral and carotid) and intrameningeal (spinal, basilar and middle cerebral) arteries isolated from dogs. 2. In the extrameningeal arteries, transmural electrical stimulation produced a phasic contraction. This contraction was abolished by tetrodotoxin, prazosin and guanethidine. However, alpha,beta-methylene ATP and NG-nitro-L-arginine (L-NOARG) had no significant effect on the contractile responses. 3. In the intrameningeal arteries, the neurogenic responses to electrical stimulation were composed of a transient contraction and relaxation. The transient contraction was selectively inhibited by guanethidine L-NOARG abolished the relaxation but not the contraction induced by electrical stimulation. Prazosin had no effect on either neurogenic response. 4. Noradrenaline produced a large contraction in the extrameningeal arteries which was selectively inhibited by prazosin. alpha,beta-Methylene ATP produced neither contraction nor inhibition of the response to noradrenaline in the extrameningeal arteries. 5. In the intrameningeal arteries, alpha,beta-methylene ATP produced a greater contraction than noradrenaline. T...Continue Reading

References

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Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·T TsukaharaH Handa
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Aug 1, 1972·Circulation Research·L G D'Alecy, E O Feigl
Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·Y SakakibaraI Muramatsu

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