Heterogeneity of NK Cells and Other Innate Lymphoid Cells in Human and Murine Decidua

Frontiers in Immunology
Paola VaccaLorenzo Moretta

Abstract

Innate lymphoid cells (ILCs) represent a heterogeneous group of cells lacking genetically rearranged antigen receptors that derive from common lymphoid progenitors. Five major groups of ILCs have been defined based on their cytokine production pattern and developmental transcription factor requirements: namely, natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue-inducer (LTi) cells. ILC1s, ILC2s, and ILC3s mirror the corresponding T helper subsets (Th1, Th2, and Th17, respectively) and produce cytokines involved in defense against pathogens, lymphoid organogenesis, and tissue remodeling. During the first trimester of pregnancy, decidual tissues contain high proportion of decidual NK (dNK) cells, representing up to 50% of decidual lymphocytes, and ILC3s. They release peculiar cytokines and chemokines that contribute to successful pregnancy. Recent studies revealed that ILCs display a high degree of plasticity allowing their prompt adaptation to environmental changes. Decidual NK cells may derive from peripheral blood NK cells migrated when pregnancy establishes or from in situ differentiation of hematopoietic precursors. Previous studies showed that human and murine decidua contain dNK cells, tissue resident NK c...Continue Reading

References

Jan 1, 1996·Annual Review of Immunology·A MorettaL Moretta
Nov 4, 2000·Journal of Reproduction and Fertility·S A RobertsonK I Matthaei
Jul 10, 2002·Trends in Immunology·Ashley Moffett-KingDavid Bainbridge
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Oct 22, 2003·The Journal of Experimental Medicine·Louise A KoopmanJack L Strominger
Dec 21, 2004·Molecular Immunology·John R Ortaldo, Howard A Young
Oct 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hernan D KopcowJack L Strominger
Jul 27, 2006·Nature Reviews. Immunology·Ashley Moffett, Charlie Loke
Sep 9, 2006·Nature Medicine·Philippe Le Bouteiller, Julie Tabiasco
Oct 3, 2006·Nature Immunology·Christian A J VosshenrichJames P Di Santo
Nov 15, 2006·Immunological Reviews·Aharon G Freud, Michael A Caligiuri
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Derin B KeskinJack L Strominger
Apr 4, 2007·Trends in Immunology·Jacob Hanna, Ofer Mandelboim
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Angela SantoniAngela Gismondi
Jul 25, 2008·Blood·Michael A Caligiuri
May 12, 2010·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoMika Ito
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Paola VaccaMaria Cristina Mingari
Jan 8, 2011·Science·Eric VivierSophie Ugolini
Jan 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paola VaccaMaria Cristina Mingari
Mar 16, 2011·Annals of the New York Academy of Sciences·Gil MorSeth Guller
Jun 8, 2011·The Journal of Clinical Investigation·Laetitia A MautiIvan Stamenkovic
Sep 6, 2011·Trends in Immunology·Paola VaccaMaria Cristina Mingari
Sep 24, 2011·Nature Reviews. Immunology·Fu-Dong ShiLuc Van Kaer
Jan 10, 2013·Annual Review of Immunology·Adrian Erlebacher
Jan 22, 2013·Nature Immunology·Jochem H BerninkHergen Spits
Feb 26, 2013·Journal of Reproductive Immunology·Paola VaccaLorenzo Moretta
Apr 18, 2013·PLoS Pathogens·Johan SiewieraNabila Jabrane-Ferrat
Sep 17, 2013·Nature·Jesse C NussbaumRichard M Locksley
Nov 2, 2013·Haematologica·Laura ChiossoneMaria Cristina Mingari
Feb 11, 2014·Nature·Michael G ConstantinidesAlbert Bendelac
Feb 25, 2014·Seminars in Immunology·Elisa MontaldoMaria Cristina Mingari
Mar 19, 2014·Frontiers in Immunology·Lorenzo MorettaMaria Cristina Mingari

❮ Previous
Next ❯

Citations

Nov 14, 2019·Cellular and Molecular Life Sciences : CMLS·Qiyao ChaiCui Hua Liu
Jan 15, 2020·Nature Reviews. Rheumatology·Frauke Förger, Peter M Villiger
Aug 26, 2020·HLA : Immune Response Genetics·Michael EikmansSebastiaan Heidt
Nov 30, 2019·Development·Margherita Y Turco, Ashley Moffett
Mar 7, 2020·Frontiers in Immunology·Nicole Meyer, Ana Claudia Zenclussen
Jun 26, 2020·Frontiers in Immunology·Nathalie LédéeGerard Chaouat
Apr 1, 2020·Frontiers in Oncology·Valentina BrunoEnrico Vizza
Feb 11, 2020·Frontiers in Immunology·Jessica VazquezAleksandar K Stanic
Nov 17, 2020·Frontiers in Immunology·Anita van der ZwanSebastiaan Heidt
Dec 18, 2020·Frontiers in Immunology·Ana Valle-NogueraAranzazu Cruz-Adalia
Nov 22, 2020·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Apr 27, 2021·European Journal of Immunology·Linda QuatriniLorenzo Moretta
Jul 9, 2021·Frontiers in Immunology·Oisín HuhnAndrew M Sharkey
Aug 8, 2021·The Journal of Allergy and Clinical Immunology·Natalia AlkonGeorg Stingl
Oct 1, 2021·American Journal of Reproductive Immunology : AJRI·Takuya SugaharaJo Kitawaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.