PMID: 6537948Feb 15, 1984Paper

Heterogeneity of plasminogen activator expression in various Moloney virus-induced tumor cell lines. Lack of correlation with tumor growth and cell phenotype

International Journal of Cancer. Journal International Du Cancer
E Anglés-CanoP Debre

Abstract

The aberrant expression of a plasminogen activator (PA) by Moloney virus (MuLV)-transformed mouse lymphocytes and its relation to cell phenotype and tumor growth have been studied. Nine cultured cell lines were established from neoplastic splenic and thymic tissues obtained from B10 congeneic mice inoculated with MuLV and killed when overtly leukemic. Cell surface markers were assayed by microcytotoxicity tests, the concentration of MuLV p30 and group-specific MuLV gp 70 was determined by radioimmunoassays and the expression of PA activity was assessed in a fibrin-agar plate method. PA activity of 24 h serum-free culture supernatant, intact cells or cell lysates (2 X 10(5) cells/ml) was expressed in International Units by reference to a urokinase standard curve. Tumor extension and cell morphology were investigated by histologic and cytomorphologic analysis. In all cases the cell lines were derived from T cells. PA activity is not expressed by normal lymphocytes, but variations in PA expression were observed in the transformed cells. Five out of nine transformed cell lines showed PA activity with a range of 1.3 to 9.9 IU/ml. No PA activity could be detected in the other cell lines. No correlation was found between PA expression...Continue Reading

References

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Citations

Dec 22, 1999·Molecular Reproduction and Development·M Jiménez DíazD Miceli
May 6, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G ScicoloneV Flores
Jul 16, 1993·Cancer Letters·D F AlonsoE Bal de Kier Joffé
Feb 15, 1989·International Journal of Cancer. Journal International Du Cancer·S Pereyra-Alfonso, E Bal de Kier Joffe
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·S Pereyra-AlfonsoE Bal de Kier Joffé
Feb 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D RouyE Anglés-Cano
Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S Pereyra-AlfonsoV Flores

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