Heterogeneity of posterior limbic perfusion in very early Alzheimer's disease

Neuroscience Research
Michinobu NagaoHitoshi Miki

Abstract

This study was designed to quantify the heterogeneity of cerebral perfusion on SPECT images in elderly controls and Alzheimer's disease (AD) patients in mild stage using a three-dimensional fractal analysis (3D-FA). Seventy-five patients with possible and probable AD based on the NINCDS/ADRDA criteria, and thirty-one elderly controls underwent 99mTc-HMPAO SPECT scanning. Dementia severity was assessed using the clinical dementia rating (CDR). Patients with CDR scores of 0.5 (n=33) were classified as "very early" and those with CDR 1 (n=42) as "early". We delineated the SPECT images using 2 cutoffs (35% and 50% cutoffs of the maximal voxel radioactivity) and measured the number of voxels in the areas included by the contours obtained with each cutoff level. The fractal dimension (FD) was calculated by relating the logarithms of cutoff level and the number of voxels. Posterior limbic images were reconstructed at 30 degrees positive to the coronal plane, and posterior limbic FD was calculated. Posterior limbic FD for early AD, very early AD, and control groups were 1.03+/-0.16, 1.02+/-0.17, and 0.87+/-0.14 (P=0.001 versus early AD group, P=0.001 versus very early AD). Use of the posterior limbic FD and the ratio of posterior limbi...Continue Reading

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Citations

Aug 27, 2013·European Radiology·Florian Michallek, Marc Dewey
Sep 21, 2010·Computer Methods and Programs in Biomedicine·J Ruiz de MirasF J Esteban
Dec 24, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Antonio Di IevaMiguel Martín-Landrove

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