PMID: 6113354Jun 27, 1981Paper

Heterogeneity of prolactin responses to oestradiol benzoate in women with prolactinomas

Lancet
M C WhiteG F Joplin

Abstract

Serum prolactin concentrations were measured for 72 h after intramuscular injection of 1 mg of oestradiol benzoate in six normoprolactinaemic women and nineteen with a prolactinoma (eleven with an obviously enlarged pituitary fossa and eight with a normal pituitary fossa). The group with an obvious tumour showed a rise in mean serum prolactin at 48 h to 122% of basal concentrations (p less than 0.05), and at 72 h to 137% of basal concentrations (p less than 0.01). Individual responses were variable, but in four patients serum prolactin rose to 165% or more of basal concentrations. In the group with a prolactinoma and a normal pituitary fossa serum prolactin at 72 h was 121% of basal concentrations (p less than 0.05). Normoprolactinaemic women showed no significant change in serum prolactin at any time. This study demonstrated a heterogeneity of serum prolactin responses to acute oestradiol administration in women with prolactinomas. Some patients with large tumours had a hypersensitive response to oestradiol. This heterogeneity of response could account for the present unpredictability of expansion of prolactinomas during pregnancy.

References

Jun 2, 1979·Lancet·E A CowdenG M Teasdale
Sep 22, 1979·British Medical Journal·A M McGregorK Hall
Sep 1, 1976·British Journal of Obstetrics and Gynaecology·S Biswas, C H Rodeck
Dec 20, 1975·British Medical Journal·M O ThornerA E Jones
Apr 1, 1974·Clinical Endocrinology·A S McNeilly, T Chard
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·M O ThornerR M MacLeod

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Citations

Dec 1, 1989·British Journal of Obstetrics and Gynaecology·J S BevanJ R Peters
Feb 27, 2003·Journal of Endocrinological Investigation·I Chiodini, A Liuzzi
Dec 12, 1981·British Medical Journal·C R Edwards, C M Feek
Nov 1, 1988·Medical Toxicology and Adverse Drug Experience·K Hell, H Wernze

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