Heterogeneity of pseudohypoparathyroidism type I from the aspect of urinary excretion of calcium and serum levels of parathyroid hormone

Calcified Tissue International
K MizunashiK Yoshinaga

Abstract

Urinary excretion of calcium (Ca) was measured in 9 patients with pseudohypoparathyroidism (PHP) type I--3 with Albright's hereditary osteodystrophy (AHO): AHO(+) and 6 without AHO: AHO(-)--and in 13 with idiopathic hypoparathyroidism (IHP), treated with active vitamin D3 (1,25(OH)2D3 or 1 alpha OHD3) to maintain serum Ca levels at 8.4-9.5 mg/dl. Fasting urinary excretion of Ca in PHP was significantly lower than that in IHP. Moreover, fasting urinary excretion of Ca in PHP AHO(+) was lower than that in PHP AHO(-). This difference was also seen in the urine after oral loading of Ca. Urinary excretion of sodium (Na) was not different between PHP AHO(+) and PHP AHO(-). Serum levels of immunoreactive PTH in PHP AHO(+) were higher than those in PHP AHO(-). The difference in urinary excretion of Ca between PHP AHO(+) and PHP AHO(-) may come from the difference in the circulating levels of PTH.

References

Jul 1, 1977·Metabolism: Clinical and Experimental·T K SinhaN H Bell
Apr 1, 1976·The Journal of Clinical Endocrinology and Metabolism·M K DreznerH E Lebovitz
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M YamamotoE Ogata
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J SilverL M Sherwood
Aug 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J Mitchell, D Goltzman
Oct 1, 1969·The Journal of Clinical Investigation·L R ChaseG D Aurbach
Nov 15, 1973·The New England Journal of Medicine·M DreznerH E Lebovitz
Oct 1, 1974·The Journal of Clinical Endocrinology and Metabolism·H J RodriguezE Slatopolsky
Jun 1, 1980·The American Journal of Medicine·N A BreslauA M Moses
Dec 1, 1980·The Journal of Clinical Endocrinology and Metabolism·L Aksnes, D Aarskog
Jan 1, 1983·Vitamins and Hormones·S J MarxC Eil
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·N LoveridgeJ Chayen
Feb 1, 1980·Annals of Internal Medicine·R S MasonS Posen
Jan 1, 1950·Acta Endocrinologica·H ELRICKJ D REEVES
Sep 1, 1948·The Journal of Clinical Investigation·J Brod, J H Sirota

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Citations

Jan 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S Ish-ShalomT M Murray
Feb 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M MunakataK Abe
Jun 28, 2012·The Journal of Clinical Endocrinology and Metabolism·Nicola M NearyLee S Weinstein
Oct 18, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jennifer Park-SigalMorris Schambelan
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Yuriko HatakeyamaTeruo Igarashi
Aug 24, 2001·Journal of the American Society of Nephrology : JASN·Masako GotoYohtaro Furukawa

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