Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes

British Journal of Haematology
M L Freedman, S Karpatkin

Abstract

Rabbits were either splenectomized or subjected to splenic blockade with phenylhydrazine in order to determine the splenic platelet and megathrombocyte (large-platelet) pools. The average splenic platelet pool calculated from both methods was 35% of total platelets. The average splenic megathrombocyte pool was 54% of total megathrombocytes. Adrenaline injection into rabbits or dogs revealed a rapid increase in both platelet count and megathrombocyte number which peaked at 2-6 min and returned toward normal in 5-10 min. The platelet volume distribution curve was shifted to the right, indicating the release of large platelets (megathrombocytes) into the circulation. The peak rise in megathrombocyte number was significantly greater than the peak rise in platelet count. Rabbits subjected to splenic massage shifted their platelet volume distribution curve to the right in the absence of a rise in platelet count. It is concluded that the spleen preferentially sequesters megathrombocytes.

References

Mar 1, 1974·British Journal of Haematology·S Karpatkin, S K Garg
Feb 11, 1973·The American Journal of Physiology·L Wade
Jul 1, 1971·The American Journal of Medicine·S KarpatkinG W Siskind

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Citations

Mar 1, 1979·Digestive Diseases and Sciences·M H RubinR Williams
Mar 1, 1988·Journal of Autism and Developmental Disorders·E GellerE Ritvo
Jun 1, 1987·Irish Journal of Medical Science·B HardingE Egan
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Jan 20, 2010·Journal of Theoretical Biology·Markus ScholzMarkus Loeffler
Apr 1, 1978·The American Journal of Medicine·S KarpatkinM Freedman
Mar 7, 2019·PLoS Computational Biology·Yuri Kheifetz, Markus Scholz
May 12, 2019·Autism Research : Official Journal of the International Society for Autism Research·Nurdan CobanBaran Calisgan
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Jul 1, 1995·Blood Pressure·I F IslimD G Beevers
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Mar 1, 1987·The American Journal of Physiology·S G RosenA J Zweifler
Sep 11, 1978·Biochimica Et Biophysica Acta·K J Hwang, A W Wase

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