Heterogeneity of rabbit platelets. VI. Further resolution of changes in platelet density, volume, and radioactivity following cohort labelling with 75Se-selenomethione

British Journal of Haematology
S Karpatkin

Abstract

Rabbits were injected intravenously with a cohort platelet label, 75Se-selenomethionine Platelet-rich plasma was separated into five different platelet density fractions on each of seven days by repetitively centrifuging the same sample of platelet-rich plasma at increasing gravitational force. The heaviest platelet sediment fraction was enriched with smaller platelets. Incorporation of isotope into the heaviest platelet fraction was considerably greater than incorporation into the highest platelet fraction, i.e. heavy--light specific activity ratio was 9.63, on day 1. The ratio of the heaviest platelet fraction specific activity to the specific activities of the platelets sedimented at higher g forces (lighter-smaller platelets), generally decreased on each day for 4--6 d by a factor of 2.8--7.0-fold. Whereas incorporation of isotope into the heaviest platelet fraction declined on days 3--4, incorporation into the lightest three fractions remained the same. Cohort platelet survival curves revealed a significant lag period of 1--2 d for the incorporation of isotope into the lightest three platelet fractions compared to the heaviest two platelet fractions. The mean platelet survival of the lightest two fractions was significant...Continue Reading

References

Jun 1, 1976·British Journal of Haematology·C A Ludlam, J D Cash
Nov 1, 1976·British Journal of Haematology·D G PeningtonJ R McGready
Dec 1, 1976·British Journal of Haematology·D G PeningtonA E Roxburgh
Oct 1, 1974·The American Journal of Medicine·S KarpatkinM L Freedman
Jan 7, 1971·The New England Journal of Medicine·S K GargS Karpatkin
Sep 1, 1971·The Journal of Clinical Investigation·B LymanS Karpatkin
Apr 1, 1966·Metabolism: Clinical and Experimental·H K AwwadJ B Dealy

❮ Previous
Next ❯

Citations

Jan 1, 1984·American Journal of Hematology·D MezzanoP Lira
Feb 1, 1984·British Journal of Haematology·S Karpatkin
Jan 1, 1981·American Journal of Hematology·D MezzanoR H Aster
Feb 15, 1989·Klinische Wochenschrift·D TschöpeF A Gries
Nov 1, 1982·American Journal of Hematology·B BoneuP Sie
Feb 1, 1984·Scandinavian Journal of Haematology·K G Schmidt, J W Rasmussen
Jul 1, 1983·British Journal of Haematology·J F MartinD G Penington
Aug 24, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Ebru TekbasMehmet S Ulgen
Feb 1, 1994·American Journal of Industrial Medicine·R M ChaseB Heath
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·B van der Loo, J F Martin
Sep 29, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nurdan CayEvrim Ozmen
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·E M DemetJ Ocariz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.