Heterogeneity of rat encephalitogenic T cells elicited by variants of the myelin basic protein (68-86) peptide

European Journal of Immunology
D SunX Hu

Abstract

By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those induced by the wild-type peptide or by intact MBP. Rather, the pathogenic T cells differed in clonal composition as reflected by their heterogeneous responses to a panel of variant peptides and by their T cell receptor usage. Thus, molecules mimicking the MBP(68-88) autoantigen can elicit pathogenic T cell subsets without necessarily cross-reacting with T cells specific for the original autoantigen. This suggests that a more clonally diverse group of pathogenic T cells might be involved in EAE than has been apparent from studies with intact MBP or its unaltered peptides.

References

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Citations

Apr 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dongchun LiangDeming Sun
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui ShaoDeming Sun
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui ShaoDeming Sun
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui ShaoDeming Sun
Jun 16, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Minhee K KoDeming Sun

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