PMID: 9420705May 1, 1994Paper

Heterogeneity of regional nitrogen 13-labeled ammonia tracer distribution in the normal human heart: comparison with rubidium 82 and copper 62-labeled PTSM

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
R S B BeanlandsM Schwaiger

Abstract

Recent reports on 13N-labeled ammonia (13N-ammonia) positron emission tomographic (PET) imaging have suggested a relative reduction of measured tracer activity in the posterolateral wall. Such inhomogeneity of tracer distribution could potentially affect accuracy for detection of disease. The aim of this study was to compare the regional distribution of 13N-ammonia with 82Rb and 62Cu-labeled PTSM (62Cu-PTSM) to identify tracer-specific patterns that may be important in the clinical interpretation of cardiac flow studies. Twenty-eight healthy volunteers underwent PET imaging at rest with either 13N-ammonia (n = 14), 82Rb (n = 8), or 62Cu-PTSM (n = 6). Eight subjects given 13N-ammonia also underwent imaging after adenosine. Activity measured in the posterolateral wall on transaxial images was significantly lower than in the septum for 13N-ammonia, both at rest (p < 0.005) and after adenosine (p < 0.05). No differences were detected for 82Rb or 62Cu-PTSM. The septum/posterolateral wall activity ratios for 13N-ammonia, 82Rb, and 62Cu-PTSM were 1.15 +/- 0.07, 1.00 +/- 0.06, and 0.97 +/- 0.08, respectively (p < 0.001). Regional analysis of image data showed the percent of maximal activity data for 13N-ammonia in the lateral wall to b...Continue Reading

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Citations

May 1, 1995·Journal of the American College of Cardiology·D S BachW F Armstrong
Jan 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·George A Beller, Steven R Bergmann
Aug 21, 2007·Augmentative and Alternative Communication : AAC·D Jeffery HigginbothamKevin Caves
Oct 8, 2013·Seminars in Nuclear Medicine·Brian McArdleRob S Beanlands
Jul 26, 2011·Seminars in Nephrology·Mark A Green, Gary D Hutchins
Jun 15, 2010·Clinical Radiology·C NanniS Fanti
Mar 22, 2008·Nuclear Medicine and Biology·Nathan E BaskenMark A Green
Mar 27, 2007·Nuclear Medicine and Biology·Mark A GreenGary D Hutchins
Nov 23, 2015·Cardiology Clinics·Daniel JuneauRob S B Beanlands
Aug 16, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L PresottoV Bettinardi
Jul 10, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken DilsizianMark I Travin
Apr 21, 2004·Clinical Nuclear Medicine·Kathleen T HickeySteven R Bergmann
Jan 18, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·C Rischpler, S G Nekolla
Aug 16, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dominik A SteffenRonny R Buechel
Nov 12, 2020·EJNMMI Radiopharmacy and Chemistry·Isaac M JacksonPeter J H Scott
Aug 1, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard C Brunken
May 30, 2021·Seminars in Nuclear Medicine·Vasvi Singh, Sharmila Dorbala

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