Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy

Heart
T S KatoM Yokota

Abstract

To evaluate regional and global left ventricular (LV) function and LV wall thickness (LVWT) in patients with hypertrophic cardiomyopathy (HCM). Observational study at the National Cardiovascular Centre and Nagoya University Hospital in Japan. Thirty-six patients with HCM and 16 patients with hypertensive LV hypertrophy (LVH). Conventional echocardiography and strain rate (SR) imaging derived from tissue Doppler imaging were performed. Systolic strain (epsilon(sys)), peak systolic SR (SR(sys)), peak early diastolic SR (SR(dia)) and LVWT were obtained from eight LV segments. LV pressure was simultaneously recorded with a high-fidelity micromanometer. The regional epsilon(sys) and SR(sys) were correlated with LVWT in patients with HCM (r = 0.50, p<0.001 and r = 0.63, p<0.001, respectively) but not in patients with hypertensive LVH. The standard deviations of LVWT, epsilon(sys) and SR(sys) obtained from the eight LV segments of each subject were greater for patients with HCM than for patients with hypertensive LVH. The standard deviation of LVWT was correlated with those of epsilon(sys) and SR(sys) (r = 0.55, p<0.001 and r = 0.56, p<0.001, respectively). The standard deviations of LVWT, epsilon(sys) and SR(sys) were correlated with...Continue Reading

Citations

Jan 16, 2009·The International Journal of Cardiovascular Imaging·Gillian C NesbittJae K Oh
Sep 22, 2010·The American Journal of Cardiology·Valentina O PuntmannIngo Paetsch
Jun 28, 2011·Circulation Research·Houman AshrafianHugh Watkins
Jun 19, 2010·Journal of Cardiovascular Translational Research·Valentin FusterMarc A Miller
May 12, 2010·Nature Reviews. Cardiology·Maja CikesBart H Bijnens
Jun 11, 2015·Expert Review of Cardiovascular Therapy·Parash PokharelJonathan N Bella

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