Heterogeneity of Second-Line Treatment for Patients With Multiple Myeloma in the Connect MM Registry (2010-2016)

Clinical Lymphoma, Myeloma & Leukemia
Sundar JagannathRobert M Rifkin

Abstract

The treatment landscape for multiple myeloma (MM) has undergone recent changes with the regulatory approval of several new therapies indicated for second- and later-line disease. Using data from Connect MM, the largest multisite, primarily community-based, prospective, observational registry of MM patients in the United States, selection of second-line treatments was evaluated during a 5-year period from 2010 to 2016. Eligible patients were aged ≥ 18 years, had newly diagnosed MM ≤ 2 months before study entry, and were followed for up to 8 years. Patients who received ≥ 2 lines of therapy were analyzed. "Tepee" plots of stacked area graphs differentiated treatments by color to allow visualization of second-line treatment trends in MM patients. As of February 2017, 855 of 2897 treated patients had progressed to second-line treatment. Treatment selection was heterogeneous; shifting patterns of treatment choices coincided with the approval status of newer agents. The most common treatment regimens in the early part of the decade were lenalidomide and/or bortezomib, with or without dexamethasone, with increasing use of newer agents (carfilzomib, pomalidomide, daratumumab, and elotuzumab) and triplet combinations over time. The infl...Continue Reading

Associated Clinical Trials

Citations

Feb 21, 2019·Expert Opinion on Pharmacotherapy·Jessica L DempseyHillard M Lazarus
Nov 9, 2019·Cancer Medicine·Sikander AilawadhiUNKNOWN Connect MM Registry Investigators
Mar 8, 2020·Clinical Lymphoma, Myeloma & Leukemia·Sundar JagannathUNKNOWN CONNECT MM Registry Investigators
Mar 15, 2021·Clinical Lymphoma, Myeloma & Leukemia·Ioannis Ntanasis-StathopoulosMeletios A Dimopoulos

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