Heterogeneity of T Cell Responses to Pandemic pH1N1 Monovalent Vaccine in HIV-Infected Pregnant Women

AIDS Research and Human Retroviruses
Adriana WeinbergP1086 Study Team

Abstract

We investigated the Th1 protective and regulatory T and B cell (Treg and Breg) responses to pH1N1 monovalent influenza vaccine (IIV1) in HIV-infected pregnant women on combination antiretroviral therapy (cART). Peripheral blood mononuclear cells (PBMCs) from 52 study participants were cryopreserved before and after vaccination and analyzed by flow cytometry. pH1N1-specific Th1, Treg, and Breg responses were measured in PBMCs after in vitro stimulation with pH1N1 and control antigen. The cohort analysis did not detect changes in pH1N1-Th1, Treg, or Breg subsets postvaccination. However, individual analyses distinguished subjects who mounted vigorous Th1 responses postvaccination from others who did not. Postvaccination, high pH1N1-Th1 correlated with high pH1N1-Treg and Breg responses, suggesting that low influenza effector responses did not result from excessive vaccine-induced immune regulation. High postvaccination pH1N1-Th1 responses correlated with baseline high PHA- and pH1N1-IFN-γ ELISpot and circulating CD4(+)CD39(+)% and CD8(+)CD39(+)% Treg, with low CD8(+) cell numbers and CD19(+)FOXP3(+)% Breg, but not with CD4(+) cell numbers or HIV viral load. These data highlight the heterogeneity of T cell responses to vaccines in...Continue Reading

References

Jul 23, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Allan R TenorioAlan Landay
Jun 29, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adriana WeinbergUNKNOWN IMPAACT P1057 Team
Jul 31, 2010·The Journal of Infectious Diseases·Chiara AgratiFederico Martini
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shabir A MadhiIan Sanne
Oct 11, 2011·The Pediatric Infectious Disease Journal·Steven BlackRino Rappuoli
Oct 15, 2011·The Journal of Infectious Diseases·Suzanne E OhmitArnold S Monto
May 4, 2012·The Journal of Infectious Diseases·Gabriel K PedersenRebecca J Cox
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Feb 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark J AbzugUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1086 Protocol Team
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Jul 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily A HemannKevin L Legge
Mar 29, 2014·The Journal of Infectious Diseases·Tim K TsangBenjamin J Cowling
Dec 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrey BaeyensBenoît L Salomon

❮ Previous
Next ❯