PMID: 2116998Aug 15, 1990Paper

Heterogeneity of the motility responses in malignant tumor cells: a biological basis for the diversity and homing of metastatic cells

International Journal of Cancer. Journal International Du Cancer
E C KohnE Schiffmann

Abstract

Tumor metastasis requires highly motile cells that can respond to appropriate stimuli. A2058 human melanoma cells were shown previously to secrete a highly potent autocrine motility factor (AMF) that stimulates chemokinetic movement. We have shown that the insulin polypeptides (IPs; insulin-like growth factors I and II [IGF-I, -II] and insulin) stimulated A2058 cell chemotaxis and chemokinesis. We now report that the IPs and AMF stimulate locomotion in other human malignant cell lines. Insulin (100 nM) induced motility of up to 50% of the magnitude of the AMF response in human carcinoma lines MDA-231 (breast), T24 (bladder), and OVCAR3 (ovarian). The tumorigenic and metastatic 5R Haras-transfected rat embryo fibroblast cell line responded to insulin with both chemotaxis and chemokinesis and was 100% of that seen for AMF. The ED50 for IGF-I in the carcinoma cell lines was in the order of I nM, but the magnitude of the responses at this concentration was 40% of the AMF-stimulated response, with the exception of the A2058 cells, which were maximally stimulated at I nM. IGF-II induced maximal motility of 75 to 130% of the AMF-stimulated response in the carcinoma lines with ED50 of less than or equal to 10 nM. IGF-II-stimulated moti...Continue Reading

References

Jan 30, 1990·Biochemical and Biophysical Research Communications·E C KohnE Schiffmann
Apr 1, 1990·The Journal of Cell Biology·S AznavoorianL A Liotta
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·U M WewerR Albrechtsen
Apr 15, 1988·Biochemical and Biophysical Research Communications·D D De LeonR G Rosenfeld
Jan 1, 1988·British Journal of Cancer·V M MacaulyJ L Millar
Jan 1, 1985·Annual Review of Physiology·E R FroeschJ Zapf
Jan 1, 1988·Methods in Enzymology·P C Wilkinson, W S Haston
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L A LiottaE Schiffmann
Jun 30, 1988·Biochemical and Biophysical Research Communications·M L StrackeE Schiffmann
Nov 15, 1987·International Journal of Cancer. Journal International Du Cancer·U RodeckH Koprowsk
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B F SloaneK V Honn
Jul 15, 1987·Biochemical and Biophysical Research Communications·M L StrackeE Schiffmann
Nov 15, 1987·International Journal of Cancer. Journal International Du Cancer·J M CulouscouG Pommier
Aug 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M GrantT J Merimee
Dec 1, 1985·The Journal of Cell Biology·V P TerranovaT Maciag
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G J TodaroJ E De Larco
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A J D'ErcoleL E Underwood
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·H MensingP K Müller
Feb 1, 1982·The Journal of Cell Biology·H SeppäG R Martin

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Citations

Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·C G BredinJ Klominek
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Rinat EshelIsaac P Witz
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·B A TeicherD Northey
Mar 1, 1994·Cancer Metastasis Reviews·K Cole, E Kohn
Jan 1, 1992·Breast Cancer Research and Treatment·K J CullenC Singer
Nov 1, 1991·Pharmacology & Therapeutics·E C Kohn
Jun 1, 1996·Journal of Dermatological Science·F WachR Hein
Aug 1, 1995·Critical Reviews in Oncology/hematology·B A Teicher
Jan 1, 1997·Trends in Endocrinology and Metabolism : TEM·P S Leventhal, E L Feldman
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·D PragerS Melmed
Jun 1, 1995·International Journal of Urology : Official Journal of the Japanese Urological Association·T KakizoeM Tachibana
Jul 31, 2002·The Lancet Oncology·Shi-Ming TuChristopher J Logothetis
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·J T PriceE C Kohn
Nov 11, 1991·International Journal of Cancer. Journal International Du Cancer·M SeikiE Schiffmann
Nov 23, 2006·The International Journal of Biochemistry & Cell Biology·Marina A Guvakova
Feb 7, 2007·Microscopy Research and Technique·Lilian SoonJohn Condeelis
Jun 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tanja NussbaumKai Breuhahn
Nov 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J M Chiang, J Y Wang
Aug 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K I Pritchard
Jan 6, 2001·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·M R BrownE C Kohn
Apr 10, 2012·PloS One·Jeomil BaeWoo Keun Song
Feb 15, 1993·Cancer·S AznavoorianL A Liotta
Nov 6, 2003·Clinical Orthopaedics and Related Research·Peter F M Choong
Nov 15, 1996·The Journal of Biological Chemistry·R S WarrenD B Donner
Apr 1, 1993·International Journal of Cancer. Journal International Du Cancer·E C KohnE Schiffmann

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